Lung epithilial secretes CHEMOKINES?
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Lung epithelial cells secrete chemokines such as CXCR2 ligands, CXC-chemokines, and monocyte chemotactic protein-1 (MCP-1) and interleukin-8 (IL-8) . These chemokines play a role in regulating immune responses, inflammation, and cell migration in the lung. The secretion of chemokines by lung epithelial cells is influenced by various factors, including cytokines, infection with pathogens such as Pseudomonas aeruginosa and Mycobacterium tuberculosis, and the process of epithelial to mesenchymal transition (EMT) in lung cancer . The production of chemokines by lung epithelial cells can contribute to the recruitment and activation of immune cells, such as neutrophils, monocytes, lymphocytes, and polymorphonuclear cells, in the lung .
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| Papers (5) | Insight |
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| The paper states that the human alveolar epithelial cell line A549 produces chemokines, specifically monocyte chemotactic protein-1 (MCP-1) and interleukin-8 (IL-8), in response to Mycobacterium tuberculosis infection. | |
43 Citations | The paper does not specifically mention whether lung epithelial cells secrete chemokines. The paper primarily focuses on the regulation of lung epithelial sodium channels by cytokines and chemokines during inflammatory disease. |
42 Citations | The paper does not mention whether lung epithelial cells secrete chemokines. |
| Yes, according to the paper, lung epithelial cells produce chemokines in response to IL-17 stimulation. | |
| Yes, the paper states that the airway epithelium releases CXC-chemokines after infection, which incites airway inflammation. |
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