J
Joachim Müller-Quernheim
Researcher at University of Freiburg
Publications - 209
Citations - 11440
Joachim Müller-Quernheim is an academic researcher from University of Freiburg. The author has contributed to research in topics: Bronchoalveolar lavage & Lung. The author has an hindex of 50, co-authored 201 publications receiving 10302 citations. Previous affiliations of Joachim Müller-Quernheim include University Medical Center Freiburg.
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Journal ArticleDOI
Acute Exacerbations of Idiopathic Pulmonary Fibrosis
Harold R. Collard,Bethany B. Moore,Kevin R. Flaherty,Kevin K. Brown,Robert J. Kaner,Talmadge E. King,Joseph A. Lasky,James E. Loyd,Imre Noth,Mitchell A. Olman,Ganesh Raghu,Jesse Roman,Jay H. Ryu,David A. Zisman,Gary W. Hunninghake,Thomas V. Colby,Jim J. Egan,David M. Hansell,Takeshi Johkoh,Naftali Kaminski,Dong Soon Kim,Yasuhiro Kondoh,David A. Lynch,Joachim Müller-Quernheim,Jeffrey L. Myers,Andrew G. Nicholson,Moisés Selman,Galen B. Toews,Athol U. Wells,Fernando J. Martinez +29 more
TL;DR: An international effort to summarize the current state of knowledge regarding acute exacerbations of IPF is presented, and proposed diagnostic criteria include subjective worsening over 30 days or less, new bilateral radiographic opacities, and the absence of infection or another identifiable etiology.
Journal ArticleDOI
Infliximab therapy in patients with chronic sarcoidosis and pulmonary involvement.
Robert P. Baughman,Marjolein Drent,Mani S. Kavuru,Marc A. Judson,Ulrich Costabel,Roland M. du Bois,Carlo Albera,Martin Brutsche,Gerald S. Davis,James F. Donohue,Joachim Müller-Quernheim,Rozsa Schlenker-Herceg,Susan Flavin,Kim Hung Lo,Barry Oemar,Elliot S. Barnathan +15 more
TL;DR: The results of this Phase 2 clinical study support further evaluation of anti-TNF-alpha therapy in severe, chronic, symptomatic sarcoidosis.
Journal ArticleDOI
Sarcoidosis is associated with a truncating splice site mutation in BTNL2.
Ruta Valentonyte,Jochen Hampe,Klaus Huse,Philip Rosenstiel,Mario Albrecht,Annette Stenzel,Marion Nagy,Karoline I. Gaede,Andre Franke,Robert Haesler,Andreas Koch,Thomas Lengauer,Dirk Seegert,Norbert Reiling,Stefan Ehlers,Eberhard Schwinger,Matthias Platzer,Michael Krawczak,Joachim Müller-Quernheim,Manfred Schürmann,Stefan Schreiber +20 more
TL;DR: A systematic three-stage SNP scan of 16.4 Mb on chromosome 6p21 in as many as 947 independent cases of familial and sporadic sarcoidosis and found that a 15-kb segment of the gene butyrophilin-like 2 (BTNL2) was associated with the disease.
Journal ArticleDOI
A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18.
Antje Prasse,Dmitri V. Pechkovsky,Galen B. Toews,Wolfgang Jungraithmayr,Florian Kollert,Torsten Goldmann,Ekkehard Vollmer,Joachim Müller-Quernheim,Gernot Zissel +8 more
TL;DR: The findings suggest that AMs from patients with pulmonary fibrosis disclose a phenotype of alternative activation and might be a part of a positive feedback loop with lung fibroblasts perpetuating fibrotic processes.
Journal ArticleDOI
Toward the blood-borne miRNome of human diseases
Andreas Keller,Petra Leidinger,Andrea S. Bauer,Abdou ElSharawy,Jan Haas,Christina Backes,Anke Wendschlag,Nathalia Giese,Christine Tjaden,Katja Ott,Jens Werner,Thilo Hackert,Klemens Ruprecht,Hanno Huwer,Junko Huebers,Gunnar Jacobs,Philip Rosenstiel,Henrik Dommisch,Arne S. Schaefer,Joachim Müller-Quernheim,Bernd Wullich,Bastian Keck,Norbert Graf,Joerg Reichrath,Britta Vogel,Almut Nebel,Sven Uwe Jager,Peer F Staehler,Ioannis Amarantos,Valesca Boisguerin,Cord F Staehler,Markus Beier,Matthias Scheffler,Markus W. Büchler,J Wischhusen,Sebastian F M Haeusler,Johannes Dietl,Sylvia Hofmann,Hans-Peter Lenhof,Stefan Schreiber,Hugo A. Katus,Wolfgang Rottbauer,Benjamin Meder,Joerg Hoheisel,Andre Franke,Eckart Meese +45 more
TL;DR: In a multicenter study, the expression profiles of 863 microRNAs were determined by array analysis of 454 blood samples from human individuals with different cancers or noncancer diseases, and this 'miRNome' was validated by quantitative real-time PCR.