Penetration of alpha tocopherl in skin?
Best insight from top research papers
Alpha-tocopherol, a potent antioxidant, shows varying penetration abilities in the skin based on different formulations. Research indicates that microemulsions can enhance the delivery of alpha-tocopherol into viable skin layers, with cationic microemulsions showing the highest delivery efficiency . Additionally, alpha-tocopherol-enriched rinse-off products have been found to significantly increase the levels of alpha-tocopherol in skin barrier lipids, providing protection against photooxidative stress . Moreover, incorporating alpha-tocopherol into nanostructured lipid carriers within a thermoresponsive gel can facilitate its slow release and enhance stability, promoting better penetration across the skin barrier . Furthermore, studies on alpha-tocopherol-fatty acid ester conjugates demonstrate their ability to penetrate the skin effectively, with some conjugates being hydrolyzed to free alpha-tocopherol, influencing skin accumulation levels . Overall, these findings highlight the diverse strategies to optimize alpha-tocopherol penetration in the skin for enhanced antioxidant protection.
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| Papers (5) | Insight |
|---|---|
32 Citations | Alpha-tocopherol penetrates murine skin rapidly, with highest concentrations in the uppermost layers, particularly the stratum corneum, following topical application onto the skin. |
13 Citations | Alpha-tocopherol esters, including a-Toc-fatty acid conjugates, penetrate skin quantitatively similar to a-Toc acetate. These esters differ in hydrolysis rates, impacting skin levels and safety. |
| The study shows that an alpha-tocopherol-enriched rinse-off product effectively deposits alpha-tocopherol on the skin surface lipids, providing antioxidant protection against photooxidative stress. | |
| Alpha-tocopherol loaded lipid nanoparticles in a thermoresponsive gel enhance skin penetration due to the gel's transition at body temperature, aiding spreadability and slow release for improved efficacy. | |
40 Citations | Microemulsions influenced α-tocopherol penetration in skin, with ME-Wphy showing the highest delivery efficacy, supporting its use for enhanced antioxidant protection in the skin. |
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How does the absorption of vitamin C through the skin differ between topical and oral administration?5 answersAbsorption of vitamin C through the skin differs significantly between topical and oral administration. Topical delivery systems, such as liposomal systems like LOS and electrospun nanofiber carriers, enhance skin absorption by protecting vitamin C from degradation and improving stability. On the other hand, oral administration relies on the body's digestive processes, which can lead to lower bioavailability due to degradation in the gastrointestinal tract. Topical application of vitamin C, especially using stabilized forms like ascorbic acid 2-glucoside (AA2G), overcomes issues of chemical instability and poor skin permeability, ensuring effective delivery and utilization of vitamin C in the skin. In contrast, oral intake may face challenges in maintaining vitamin C stability and achieving optimal skin levels due to metabolic processes and absorption limitations.
Alpha tocopherl in cosmetic use?5 answersAlpha-tocopherol, a potent form of vitamin E, finds extensive application in cosmetics due to its antioxidant, anti-aging, and skin health benefits. Its low water solubility is addressed through supramolecular complexes like CD26, enhancing solubility and stability in cosmetic formulations. Vitamin E derivatives, such as alpha-tocopherol acetate, are synthesized for improved stability and water solubility, making them ideal for cosmetic use. In cosmetic formulations, alpha-tocopherol can be incorporated into metal organic chelate complexes for gradual release on the skin, acting as an anti-aging agent in cosmetotextiles. Gas chromatography techniques are employed to determine alpha-tocopherol acetate content in anti-aging cosmetic formulations, ensuring product quality and efficacy. Alpha-tocopherol's protective effects on skin cells under oxidative stress highlight its potential in preventing skin aging and related conditions, making it a valuable ingredient in cosmetics.
Does tocopheryl acetate good for hair?4 answersTocopheryl acetate has been shown to have potential benefits for hair. It is used in preparations for skin and scalp care and has been observed to be effective against head louse infestation. Tocopheryl acetate is absorbed into and retained by skin tissue, and it can be converted to free alpha-tocopherol, which is an active antioxidant. Tocopherol, tocopheryl acetate, and tocopheryl succinate have all been reported to protect against ultraviolet radiation-induced skin damage. These ingredients are generally not toxic, irritating, or sensitizing to the skin, and they have been found to have antimutagenic activity. The Cosmetic Ingredient Review Expert Panel has concluded that tocopheryl acetate is safe for use in cosmetic formulations. While there is no specific mention of the effects of tocopheryl acetate on hair in the abstracts provided, its potential benefits for the skin and scalp suggest that it could be beneficial for hair health as well.
Dose tocotrienol have skin benefits4 answersTocotrienols have been shown to have skin benefits. They protect the skin from inflammation, UV radiation, and melanin accumulation. Dietary tocotrienols accumulate in the skin and protect it from damage induced by UVB irradiation. Tocotrienols have potential protective power against UVB-induced skin inflammation. Tocotrienols also have antioxidant, anti-inflammatory, and skin barrier protective properties. They can restore cell viability, alleviate increased intracellular reactive oxygen radicals, and downregulate the activation of mitogen-activated protein kinases in skin cells. Tocotrienols can also protect skin barrier function by upregulating certain proteins involved in skin barrier maintenance. Overall, tocotrienols have been shown to have various skin benefits, including protection against UV damage, inflammation, and skin barrier dysfunction.
What substance can be enhanced skin penetration by Plai oil and how effect?5 answersPlai oil can enhance the skin penetration of piroxicam, a drug used for anti-inflammatory purposes. The study found that the highest concentration of Plai oil (5% w/w) resulted in a significant increase in the permeability coefficient of piroxicam, providing almost a 9.17-fold increase in skin transport. The enhancement effect of Plai oil on piroxicam permeation was observed in a stable gel formulation. The exact mechanism of how Plai oil enhances skin penetration is not mentioned in the abstracts provided. However, it is worth noting that Plai oil contains bioactive compounds such as sabinene, γ-terpinene, terpinene-4-ol, and (E)-1-(3,4-dimethyoxy phenyl) butadiene, which may contribute to its penetration-enhancing properties. Further research may be needed to fully understand the mechanism of action and potential applications of Plai oil as a skin penetration enhancer.
What is α-Tocopherol?5 answersα-Tocopherol, also known as vitamin E, is a potent antioxidant that scavenges reactive oxygen species and plays vital physiological roles in gene expression, cell signaling, and inhibition of platelet aggregation. It has been shown to possess neuroprotective effects and can protect against neurodegenerative diseases by reducing inflammation and preserving the morphology and function of microglial cells. α-Tocopherol derivatives have also been synthesized and tested for their cytotoxic activity against cancer cells, showing promising potential as anticancer agents with selective cytotoxicity against tumor cells. Additionally, α-Tocopherol has been found to maintain intestinal integrity and increase the expression of tight junction proteins, which are important for maintaining the barrier function of the intestine. α-Tocopherol transfer protein (α-TTP) is a protein that specifically recognizes α-Tocopherol and plays a major role in determining plasma α-Tocopherol concentrations.