Role p53 in (TNBC ?
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Mutant p53 plays a significant role in triple-negative breast cancer (TNBC). TNBC is a subtype of breast cancer that lacks effective targeted therapies. Mutations in the TP53 gene, which codes for p53 protein, are commonly found in TNBC patients. Mutant p53 not only loses its tumor-suppressor properties but also gains oncogenic activity, promoting tumor phenotypes such as proliferation, metastasis, invasiveness, and angiogenesis . The activation of HJURP, a gene associated with poor prognosis and metastasis in TNBC, is driven by mutant p53-regulated enhancers . Inhibition of bromodomain protein BRD4, which positively regulates the transcription of mutant p53, suppresses tumorigenesis in TNBC . The upregulation of mutant p53 is mediated by BRD4, and targeting BRD4 with its inhibitor JQ1 leads to the re-expression of p21, inhibition of S-phase entry, and colony formation in TNBC cells . These findings highlight the importance of mutant p53 and its regulatory mechanisms in TNBC progression and suggest potential therapeutic targets for this aggressive subtype of breast cancer.
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| Papers (4) | Insight |
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| The paper does not specifically mention the role of p53 in triple-negative breast cancer (TNBC). | |
| The paper discusses the role of mutant p53 in triple-negative breast cancer (TNBC) progression. It states that the upregulation of mutant p53 is mediated by the bromodomain protein BRD4 in TNBC cells. | |
19 Jan 2023 | The paper states that inactivation of wild type P53, by loss or mutation, increased HJURP expression in TNBC. Accumulation of wild-type P53 reduced HJURP promoter activity and HJURP transcription. |
| The paper discusses the role of mutant p53 in triple-negative breast cancer (TNBC) and its impact on cancer phenotypes such as proliferation, invasiveness, and angiogenesis. |
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