Was ambroxol tested in mice?
Best insight from top research papers
Yes, Ambroxol was tested in mice in various studies. In one study, Ambroxol was investigated for its effects on kidney damage caused by experimentally induced ischemia-reperfusion injury in rats, where Ambroxol treatment showed beneficial effects by reducing pro-inflammatory cytokines and cellular damage in tubular cells . Another study explored the anti-chlamydial effect of Ambroxol in mice infected with Chlamydia pneumoniae, demonstrating a significant decrease in recoverable C. pneumoniae units in Ambroxol-treated mice, along with increased cytokine expression and decreased ERK 1/2 activity . Additionally, Ambroxol was studied in the context of liver ischemia-reperfusion injury in rats, where it effectively reduced the release of pro-inflammatory cytokines TNF-α and IL-1β, showcasing its potential therapeutic benefits in this model .
Answers from top 5 papers
More filters
| Papers (5) | Insight |
|---|---|
| Yes, ambroxol was tested in mutant TDP-43 mice. Treatment with ambroxol at symptom onset improved motor and gait functions, preserved motor neurons, and modulated glycosphingolipid metabolism. | |
| Yes, Ambroxol was tested in rats, not mice, to investigate its effect on reducing pro-inflammatory cytokines in hepatic ischemia-reperfusion injury. | |
20 Apr 2021 | Yes, Ambroxol was tested in mice. A dose of 5 mg/kg of Ambroxol showed anti-chlamydial effects in murine lungs, potentially through immunomodulation, supporting its use in respiratory infections. |
| Yes, Ambroxol was tested in rats, not mice, to investigate its effects on kidney ischemia-reperfusion injury. | |
| Yes, Ambroxol was tested in rats, not mice, to investigate its effects on kidney ischemia-reperfusion injury. |
Related Questions
Antihypertensive assay in mice?4 answersAn antihypertensive assay in mice can be conducted using various methods described in the provided research contexts. One approach involves utilizing a genetically engineered mouse model with a variant hypertension susceptibility gene to assay compounds affecting hypertension. Additionally, the development of experimental hypertension models in mice, such as the renovascular two-kidney, one clip, and mineralocorticoid deoxycorticosterone-salt models, has been successful, allowing for the induction of hypertension in over 50% of treated mice. Furthermore, a specific and sensitive assay for angiotensin-converting enzyme 2 (ACE2) activity in mice has been developed, which could be valuable in antihypertensive drug testing and high-throughput enzymatic assays. These methods provide valuable tools for studying antihypertensive compounds and mechanisms in mouse models.
What are the effects of ambroxol on cytokine production?5 answersAmbroxol has been shown to reduce the production of pro-inflammatory cytokines TNF-α and IL-1β in various experimental models. In a study on liver ischemia-reperfusion injury in rats, Ambroxol treatment resulted in lower levels of TNF-α and IL-1β compared to the control group. Similarly, in a study on kidney damage caused by ischemia-reperfusion injury in rats, Ambroxol treatment alleviated the production of TNF-α and IL-1β, leading to reduced kidney damage. Additionally, in an experimental model of asthma in mice, Ambroxol administration suppressed the production of IL-5 and IL-13, while increasing the levels of IL-10 and IL-12 in bronchoalveolar lavage fluid. Furthermore, in a rodent model of ventilator-induced lung injury, Ambroxol inhibited lung inflammation and down-regulated the expression of c-Jun, a component of activator protein-1 (AP-1), which is involved in cytokine production. Overall, Ambroxol has demonstrated the ability to reduce cytokine production in various experimental models.
Amoxicillin dosage in mice5 answersAmoxicillin dosage in mice can vary depending on the specific study. In one study by Dai et al., mice were exposed to different doses of amoxicillin during late-pregnancy, with doses ranging from 75 to 300 mg/kg/day. Another study by Sabry examined the effects of amoxicillin on the stomach of mouse fetuses using a dose of 205 mg/kg body weight. Sabry and Rashad also studied the effects of amoxicillin on mouse fetuses, using doses of 205 and 820 mg/kg body weight. Gao et al. administered amoxicillin to juvenile mice at doses of 50 and 100 mg/kg by intragastric administration. Popper et al. used a dose of 387.11 mg/kg body weight for amoxicillin in their study. Overall, the dosage of amoxicillin in mice can vary depending on the specific experimental design and the desired outcomes of the study.
What are the effects of atenolol in mice?5 answersAtenolol has various effects in mice. One study found that treatment with atenolol led to significant increases in the concentration of creatinine in the kidneys, as well as histological damage such as necrosis and hemorrhage. Another study observed that long-term administration of atenolol in drinking water resulted in beneficial aging-related changes, including decreases in protein oxidation and oxidative damage in mitochondria. Additionally, a study on atherosclerosis in mice showed that nebivolol, a beta1-blocker similar to atenolol, attenuated the development of atherosclerosis. Furthermore, a study on male mice found that atenolol administration caused a rise in serum luteinizing hormone levels, while administration of almonds did not significantly affect these levels. Finally, a study on ob/ob mice found that atenolol exacerbated weight gain, while the sympathomimetic agent ephedrine reduced weight gain.
How is fluconazole administered to mice as a treatment?5 answersFluconazole is administered to mice as a treatment through various routes. In one study, SCID mice were inoculated orally with Candida albicans and then treated with fluconazole at different doses, ranging from 5 to 10 mg/kg per day. Another study used subcutaneous injections of fluconazole at a dose of 2.5 mg/kg, given at 6, 24, and 48 hours after infection. Additionally, mice infected with Candida albicans were treated with varying doses of fluconazole, starting one day after infection, either orally or intravenously. The specific administration route and dosage of fluconazole may vary depending on the experimental design and the specific infection model being used.
Is ambroxol safe in kidney disease?4 answers