What are knowledge gaps on bone collagen secondary structure?
Best insight from top research papers
The knowledge gaps on bone collagen secondary structure include the exact location and arrangement of apatite crystals with respect to collagen fibrils, the composition and bonding along collagen fibrils, and the differences in collagen's secondary structure and post-translational modification in bones with varying levels of mineralization . The currently accepted 2D model suggests that the crystals are located inside the gap zone of collagen fibrils, but recent studies challenge this hypothesis by reporting evidence of substantial extrafibrillar bioapatite . Additionally, the nanostructural organization within bone is not well known and is debated, with the fraction of total bioapatite distributed within fibrils estimated to be less than or equal to 0.42 inside gap channels and less than or equal to 0.28 inside intermolecular overlap regions . These knowledge gaps hinder a comprehensive understanding of bone structure and have implications for the mechanics of mineralized tissues .
Answers from top 5 papers
More filters
| Papers (5) | Insight |
|---|---|
| The paper does not specifically mention the knowledge gaps on bone collagen secondary structure. The paper discusses the difficulty in resolving the structure of bone due to the small size of the crystals. | |
| The provided paper does not specifically mention any knowledge gaps on bone collagen secondary structure. | |
| The paper does not explicitly mention the specific knowledge gaps on bone collagen secondary structure. | |
| The paper does not specifically mention knowledge gaps on bone collagen secondary structure. | |
| The paper does not explicitly mention the knowledge gaps on bone collagen secondary structure. |
Related Questions
What are the current research gaps in understanding the impact of various materials on teeth?4 answersCurrent research gaps in understanding the impact of various materials on teeth include the need for a comprehensive assessment of genotoxicity induced by dental materials like bleaching agents, restorative materials, and resin-based sealers. Additionally, there is a necessity for further investigations into the mechanical properties of human teeth, particularly enamel and dentin, to enhance artificial tooth development and understand how these properties change with age and in different oral environments. Furthermore, there is a call for audits to identify research gaps in clinical trials related to the application of glass-ionomer cements in dental practice, highlighting the importance of filling these gaps to improve the safety and efficacy of dental treatments. These gaps underscore the ongoing need for in-depth studies to ensure the safety and effectiveness of dental biomaterials.
Is there any gap in knowledge about deep eutectic solvents and polysaccharides structure modeling?5 answersDeep eutectic solvents (DESs) have advantageous properties but there is still a lack of understanding about their interfacial and bulk structure. The molecular origin of the large melting point depressions observed in DESs is not fully understood. The link between the DES liquid microstructure and its macroscopic properties is still missing. More experimental studies are needed to quantify the observed balance between interactions and disorder at the molecular level and incorporate this data into thermodynamic models. In terms of polysaccharide structure modeling, there is a need for new methodologies to disrupt the complex interactions of feedstocks and enhance their hydrolysis. Deep eutectic solvents (DESs) have been identified as important green solvents with potential for catalytic transformation of polysaccharide-rich biomass. However, there is still a gap in knowledge regarding the structural features of cellulose interacting with DESs.
Is there a gap in knowledge?4 answersThere is a gap in knowledge identified in the abstracts. The knowledge gap hypothesis suggests that as information flows into society, gaps in knowledge between high and low socioeconomic groups widen, with the former acquiring information at a faster rate. In the context of primary care, there is a knowledge gap regarding the possible causes of liver function test abnormalities in young adults. Additionally, in the field of machine learning, there is a transfer gap between the human domain and the machine domain, which affects the estimation of how much knowledge should be transferred from teacher to student. Furthermore, in the field of cardiac implantable electronic device infection prevention, there is a knowledge gap regarding postoperative prophylaxis, especially in patients undergoing complex implantation procedures. These examples highlight the existence of knowledge gaps in various domains, emphasizing the need for further research and understanding.
What are the gaps in bone tissue engineering?5 answersBone tissue engineering faces several gaps and challenges. One major gap is the inability to replicate the key characteristic of bone tissue, which is the gradual and rapid embedding of cells in a heavily calcified matrix. Another gap is the need for materials that can replicate the structure, composition, mechanics, and biology of native bone tissue. Design considerations for bone tissue engineering include biocompatibility, vascularization, and bone remodeling. Fragility of ceramic materials and poor mechanical properties of natural polymers are additional challenges. Nanotechnology offers potential solutions by enabling the delivery of bioactive molecules, cell labeling and targeting, and scaffold construction and modification. However, the translation of these technologies into clinical practice is still needed. Understanding the regulation of apoptosis in osteoblasts and its significance for bone tissue engineering is another important gap. Overall, an integrated approach that addresses clinical needs and considers all components of the bone tissue engineering construct is required.
Is there a gap in the knowledge in this paper?3 answersThere is a gap in the knowledge in the paper by Cay et al. regarding postoperative antibiotic prophylaxis in prevention of cardiac implantable electronic device infection. The authors did not provide a clear definition of revision and it is unclear whether certain procedures were included in the study. The type of randomization method used in the study was not specified, which is important for understanding the validity of the results. There is also a discrepancy in the total number of infected cases reported by the authors. Additionally, the paper highlights a knowledge gap in the current literature regarding postoperative prophylaxis in patients undergoing complex implantation procedures. Overall, the gaps in knowledge and inconsistencies in the study design prevent firm conclusions from being drawn.
What are the research gaps ?3 answersResearch gaps are areas where the current knowledge and research data are insufficient to fully address a particular research question or problem. These gaps arise due to limitations in study design, inadequate research tools, or external factors that researchers may or may not have control over. Identifying and understanding these gaps is crucial for the advancement of knowledge and the development of new research areas. The abstracts provided highlight various research gaps in different fields. For example, in the field of viral hepatitis, research gaps include poor vaccination coverage, the need for rapid and mobile testing methods, and the lack of "real world" evidence on the benefits of treatment eligibility expansion. In the field of pediatric hypertension, research gaps include the etiology, prevalence, and long-term impacts of hypertension, as well as the safety and efficacy of antihypertensive therapy in youth. In the field of FinTech, research gaps include the lack of a coherent research agenda and the need for further exploration of key themes and questions.