What are some n-glycans that can be electrochemically detected?
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N-glycans that can be electrochemically detected include Thomsen-Friedenreich (T), Tn, and sialyl-Tn (STn) antigens. These short O-glycans are associated with cancer cells and are not typically found in healthy tissues. Additionally, the brain tissue has been analyzed for N-linked glycans using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) mass spectrometry imaging, leading to the identification of unique N-glycans, including those with sialic acid residues. Furthermore, nitrogen-containing graphene electrodes have been utilized for the electrochemical oxidation of glucose, demonstrating high sensitivity and a linear range for glucose detection. Overall, these findings showcase the potential for electrochemical detection of specific N-glycans related to cancer and other biological processes.
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| Papers (5) | Insight |
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| N-glycans can be electrochemically detected using glycan-based biosensors, enhancing specificity for biomarker detection in infectious diseases and cancer, particularly colorectal cancer, at ultra-low concentrations. | |
| Thomsen-Friedenreich (T), Tn, and sialyl-Tn (STn) glycans can be electrochemically detected, showcasing potential as cancer biomarkers for screening, diagnosis, and monitoring. | |
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