What are the actions of ribozymes?
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Ribozymes, RNA enzymes, exhibit catalytic activity by cleaving specific RNA sequences, leading to reduced gene expression. They have shown potential in cancer therapeutics, genetic diseases, and combating viral and bacterial infections. Ribozymes like hammerhead, hairpin, hepatitis delta virus, and lead-dependent ribozymes have distinct structures and mechanisms of action. Trans-cleaving ribozymes have been utilized to target specific mRNAs for gene expression inhibition, while trans-splicing ribozymes can repair and reprogram pathogenic genes, offering a unique therapeutic approach. Ribozymes have been modified for HIV-1 therapy, demonstrating their versatility and potential as therapeutic agents in various conditions. Despite challenges in delivery and efficacy, ribozymes remain promising tools for RNA-based therapeutics.
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| Papers (5) | Insight |
|---|---|
25 Citations | Ribozymes act as catalysts in biological reactions, including genome cleaving, protein synthesis, and gene regulation, with potential therapeutic applications in conditions like HIV-1 infection. |
14 Citations | Ribozymes can downregulate or repair genes via RNA cleavage (trans-cleaving ribozymes) or simultaneous destruction and repair (trans-splicing ribozymes), offering selective therapeutic gene editing capabilities. |
| Ribozymes like hammerhead, twister, and hepatitis delta virus ribozymes catalyze self-cleavage reactions, revealing diverse biological functions in RNA molecules. | |
| Ribozymes act as catalytic RNA molecules that cleave specific RNA sequences, reducing gene expression. They are explored as therapeutic agents against infectious diseases caused by viral and bacterial pathogens. | |
| Ribozymes act by cleaving target mRNAs to inhibit gene expression and enabling site-directed RNA sequence alterations for correcting genetic misinformation at the RNA level. |
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