What are the current research developments in the mechanobiology of pericardium?
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Current research developments in pericardium mechanobiology encompass diverse areas. Recent studies have highlighted the significance of understanding the biomechanics of human pericardium, especially in the context of cardiovascular diseases. Advanced computational-experimental models have been employed to investigate biomechanical adaptations of the pericardium in response to conditions like pulmonary hypertension, shedding light on its role in cardiac function. In vitro models have been pivotal in studying mechanobiological cues affecting cardiac cells and tissues, emphasizing the importance of dynamic mechanical environments in influencing cell behavior and tissue responses. These studies underscore the need for further exploration of mechanobiological signals from cardiac tissues to enhance our understanding of heart pathology and potentially improve therapeutic strategies for heart diseases. Exciting advancements in in vitro modeling techniques offer promising avenues for detailed cause-effect studies on the impact of mechanobiology in cardiac physiology.
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1 Citations | Research explores pericardium's biomechanical role in hypertensive hearts, impacting ventricular function. Computational models predict compensatory changes in RV and LV contractility due to altered pericardial elasticity. |
12 Jan 2021 7 Citations | Not addressed in the paper. |
| Compression Optical Coherence Elastography (C‐OCE) is utilized to characterize human pericardium biomechanics, revealing differences in samples and emphasizing the impact of chemo‐mechanical treatment for surgical applications. | |
3 Citations | Not addressed in the paper. |
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