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What are the current research findings on the association between periodontal disease and halzimers?

Ordinal regression

Inflammatory bowel disease

Mendelian randomization

Ulcerative colitis

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Current research findings suggest a bidirectional association between periodontal disease and various systemic conditions, but there is limited evidence on the direct link with Alzheimer's disease. Studies have explored associations between periodontitis and chronic systemic diseases like diabetes, cardiovascular diseases, and inflammatory bowel disease . Additionally, research has shown a significant association between education level and periodontitis, indicating socioeconomic factors may play a role in oral health disparities . Furthermore, a systematic review highlighted a bidirectional positive association between periodontal disease and diabetes mellitus, emphasizing the need for screening patients with periodontitis for diabetes and vice versa . However, specific research on the direct relationship between periodontal disease and Alzheimer's disease is currently lacking in the provided contexts.

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Open access•Journal Article•DOI Bidirectional association between periodontal disease and diabetes mellitus: a systematic review and meta-analysis of cohort studies. Julia Stöhr, Janett Barbaresko, Manuela Neuenschwander, Sabrina Schlesinger - Show less +3 more 01 Jul 2021-Scientific Reports 54 Citations	Not addressed in the paper.
Book Chapter•DOI The Relationship Between Periodontal Diseases and Chronic Diseases Fábio Renato Manzolli Leite, Gustavo G. Nascimento - Show less +1 more 01 Jan 2021 2 Citations	Not addressed in the paper.
Journal Article•DOI A Systematic Review and Meta-Analysis of the Association Between Periodontal Disease and Severe Mental Illness Athanasios A. Angelopoulos 28 Jun 2022-Psychosomatic Medicine 1 Citations	Not addressed in the paper.
Open access•Journal Article•DOI Evidence from the Hamburg City Health Study – association between education and periodontitis Carolin Walther, Kristin Spinler, Katrin Borof, Christopher Kofahl, Guido Heydecke, Udo Seedorf, T. Beikler, C. Terschüren, André Hajek, Ghazal Aarabi - Show less +9 more 02 Sep 2022-BMC Public Health 1 Citations	Not addressed in the paper.
Journal Article•DOI Association between inflammatory bowel disease and periodontitis: A bidirectional 2-Sample Mendelian randomization study. Zhongyuan Wang, Song Li, Waresi Abudourexiti, D. Tan, Zeqian Yu, Tenghui Zhang, Chao Ding, Jianfeng Gong - Show less +7 more 25 Jan 2023-Journal of Clinical Periodontology 1 Citations	Not addressed in the paper.

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What are the most common clinical studies on periodontal disease diagnosis?5 answersThe most common clinical studies on periodontal disease diagnosis include the evaluation of diagnostic criteria used in epidemiological studies, methods for gingival crevicular fluid (GCF) sample collection and biomarker analysis, the development of a point-of-care kit for a lateral flow test (LFT) using salivary matrix-metalloproteinase (MMP)-9, and the assessment of salivary untargeted metabolomics for diagnosis. These studies highlight the importance of accurate diagnostic tools and biomarkers like IL-1β, MMP-8, and TNF-α for early detection and monitoring of periodontitis. The research emphasizes the need for precise diagnostic methods to prevent irreversible damage to periodontal tissues and improve public dental health through early detection and intervention.

What are the current research findings on the association between periodontal disease and cardiovascular health?5 answersCurrent research findings suggest a significant association between periodontal disease and cardiovascular health. Studies indicate that periodontitis may lead to higher all-cause mortality in cardiovascular disease (CVD) patients, especially those with moderate/severe periodontitis. Tooth loss, periodontitis, and poor oral hygiene are linked to an increased risk of atherosclerotic cardiovascular events, highlighting the potential role of oral health professionals in cardiovascular disease prevention. Furthermore, the presence and severity of periodontal disease are correlated with pericardial adipose tissue volume, a marker of progressive CVD, emphasizing the impact of periodontitis on cardiovascular health outcomes. Overall, while the association between periodontal disease and cardiovascular diseases is established, further research is needed to explore the causal relationship and the effectiveness of periodontal treatment in reducing CVD risk.

What is the current understanding of the link between pulmonary diseases and periodontal diseases?5 answersPeriodontal diseases have been found to be associated with various pulmonary diseases such as chronic obstructive pulmonary disease (COPD), obstructive sleep apnoea (OSA), and COVID-19 complications. There is also evidence suggesting a link between periodontal disease and lung cancer. The presence of periodontal infection and poor oral hygiene can contribute to the aspiration of oral bacteria into the lungs, leading to respiratory infections and exacerbation of pulmonary diseases. Additionally, periodontal therapy has shown positive effects in improving lung function and reducing the frequency of exacerbations in patients with pulmonary diseases. However, there is a lack of intervention studies in this area.

Research articles about the relationship between periodontal diseases and CAD?4 answersPeriodontal diseases have been found to have a relationship with cardiovascular diseases, including coronary artery disease (CAD). The chronic inflammation caused by periodontal diseases can trigger neuroinflammation, which is associated with neurological disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and major depressive disorder. Studies have shown that individuals with a history of periodontal diseases and tooth loss are at a higher risk for peripheral arterial disease and cardiovascular events. Furthermore, periodontal disease has been identified as a potential risk factor for CAD, with higher clinical attachment levels and more extensive periodontal disease being associated with CAD severity. Maintaining oral health and preventing and treating periodontal diseases are important in reducing the risk of CAD and other cardiovascular diseases.

What is the relationship between periodontitis and diabetes?5 answersPeriodontitis and diabetes have a bidirectional relationship, with periodontitis being considered a complication of diabetes. Uncontrolled diabetes and lack of periodontal treatment can lead to more severe periodontitis. Studies have shown that the severity of periodontitis is associated with glycated hemoglobin (HbA1c) levels in patients with mild diabetes. The association between periodontal disease and type 1 diabetes mellitus has also been confirmed, with higher prevalence and severity of periodontal disease in type 1 diabetes patients. Early diagnosis of diabetes in patients with periodontitis can help prevent morbidity and mortality. Treatment of diabetes can also improve periodontitis. The bidirectional relationship between diabetes and severe periodontitis has been observed, but not in mild cases.

Is there any studies of Netrin-1 and oral diseases?4 answersNetrin-1 has been studied extensively in various diseases, but there is limited research on its role in oral diseases. However, it is worth noting that netrin-1 has been implicated in inflammation and leukocyte infiltration, suggesting potential involvement in the immune response, which could be relevant to oral diseases. Additionally, netrin-1 and its receptors have been shown to play essential roles in central nervous system development and maintenance, and emerging evidence suggests their involvement in the pathogenesis of Parkinson's disease. While there is no specific mention of netrin-1 and oral diseases in the provided abstracts, further investigation may uncover its potential role in oral health and diseases.

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