What are the effects of cigarette smoking on COPD?
Best insight from top research papers
Cigarette smoking has various effects on chronic obstructive pulmonary disease (COPD). It is considered the chief leading cause of COPD . Exposure to cigarette smoke induces airway inflammation, which persists even after smoking cessation . Cigarette smoke can promote a senescent phenotype in pulmonary arterial cells, leading to increased secretion of inflammatory molecules and impaired vascular responses . Additionally, cigarette smoke induces cell death in airway epithelial cells, with the gas phase of cigarette smoke being a critical factor for COPD onset and development . Neutrophils play a crucial role in COPD development, and cigarette smoke triggers autophagy in neutrophils through platelet-activating factor receptor (PAFR), contributing to COPD progression . The interplay between oxidative stress and the immune response is observed in COPD, with smoking cessation, counseling, and pharmaceutical therapies targeting inflammation and oxidative stress being recommended for COPD treatment .
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| Papers (4) | Insight |
|---|---|
| The effects of cigarette smoking on COPD include oxidative stress, immune system dysfunction, and exacerbation of symptoms. | |
30 Citations | The effects of cigarette smoking on COPD include the promotion of COPD progression by activating platelet-activating factor receptor (PAFR) and inducing autophagic death of neutrophils. |
102 Citations | The effects of cigarette smoking on COPD include airway inflammation, altered immune response, cellular senescence, and cell death with inflammation. |
| The paper states that cigarette smoke gas phase might be a critical factor for cigarette smoking-induced COPD onset and development. |
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