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Xiaoxi Lv
Researcher at Peking Union Medical College
Publications - 45
Citations - 1121
Xiaoxi Lv is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Autophagy & Pulmonary fibrosis. The author has an hindex of 14, co-authored 39 publications receiving 673 citations. Previous affiliations of Xiaoxi Lv include Capital Medical University.
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Journal ArticleDOI
DEDD Interacts with PI3KC3 to Activate Autophagy and Attenuate Epithelial–Mesenchymal Transition in Human Breast Cancer
Qi Lv,Wei Wang,Jianfei Xue,Fang Hua,Rong Mu,Heng Lin,Jun Yan,Xiaoxi Lv,Xiaoguang Chen,Zhuo-Wei Hu +9 more
TL;DR: It is shown that death-effector domain-containing DNA-binding protein (DEDD) attenuates EMT and acts as an endogenous suppressor of tumor growth and metastasis, and expression levels of DEDD were conversely correlated with poor prognosis in patients with breast and colon cancer.
Journal ArticleDOI
TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription
Jin-mei Yu,Wei Sun,Zhen-he Wang,Xiao Liang,Fang Hua,Ke Li,Xiaoxi Lv,Xiaowei Zhang,Yuying Liu,Jiao-jiao Yu,Shan-Shan Liu,Shuang Shang,Feng Wang,Zhao-na Yang,Chen-xi Zhao,Xue-ying Hou,Pingping Li,Bo Huang,Bing Cui,Zhuo-Wei Hu +19 more
TL;DR: It is reported that expression of the pseudokinase Tribble 3 (TRIB3) positively associates with breast cancer stemness and progression and is a potential therapeutic strategy against TRIB3-overexpressed breast cancer.
Journal ArticleDOI
TRIB3 Interacts With β-Catenin and TCF4 to Increase Stem Cell Features of Colorectal Cancer Stem Cells and Tumorigenesis
Fang Hua,Shuang Shang,Yang Yuwei,Haizeng Zhang,Tian-lei Xu,Jiao-jiao Yu,Dan-dan Zhou,Bing Cui,Ke Li,Xiaoxi Lv,Xiaowei Zhang,Shan-Shan Liu,Jin-mei Yu,Feng Wang,Cheng Zhang,Bo Huang,Zhuo-Wei Hu +16 more
TL;DR: This investigation investigated whether increased TRIB3 expression promotes stem cell features of CRC cells and tumor progression by interacting with the Wnt signaling pathway and derived organoids from human and mouse colorectal tumors to analyze the function of TRIB 3 and test the effect of a peptide inhibitor.
Journal ArticleDOI
TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RARα and Inhibition of p53-Mediated Senescence
Ke Li,Feng Wang,Wen-Bin Cao,Xiaoxi Lv,Fang Hua,Bing Cui,Jiao-jiao Yu,Xiaowei Zhang,Shuang Shang,Shan-Shan Liu,Jin-mei Yu,Ming-Zhe Han,Bo Huang,Tingting Zhang,Xia Li,Jian-Dong Jiang,Zhuo-Wei Hu +16 more
TL;DR: It is reported that expression of pseudokinase Tribble 3 (TRIB3) associates positively with APL progression and therapeutic resistance, and a potential therapeutic option against APL is provided.
Journal ArticleDOI
Disrupting the TRIB3-SQSTM1 interaction reduces liver fibrosis by restoring autophagy and suppressing exosome-mediated HSC activation
Xiaowei Zhang,Ji-Chao Zhou,Dian Peng,Fang Hua,Ke Li,Jiao-jiao Yu,Xiaoxi Lv,Bing Cui,Shan-Shan Liu,Jin-mei Yu,Feng Wang,Cai-Cai Jin,Zhao-na Yang,Chen-xi Zhao,Xue-ying Hou,Bo Huang,Zhuo-Wei Hu +16 more
TL;DR: Together, stress-elevated TRIB3 expression promotes hepatic fibrosis by interacting with SQSTM1 and interfering with its functions in liver-parenchymal cells and activating HSCs, and targeting this interaction is a promising strategy for treating fibroproliferative liver diseases.