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What are the exceptions of trp channels?

Voltage-gated ion channel

Stretch-activated ion channel

Transient receptor potential channel

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Transient Receptor Potential (TRP) channels, a diverse superfamily of non-selective cation channels, have exceptions in their composition. One notable exception is the TRPN channels, which are exclusively found in invertebrates and fish, not in mammalian genomes . Another exception lies in the fact that most mammalian TRP channels, with the exception of two members, are Ca2+-permeable non-selective cation channels that can be constitutively active or gated by various physicochemical stimuli . These exceptions highlight the diversity within the TRP channel superfamily, showcasing unique characteristics and functions that contribute to their involvement in a wide array of physiological processes and cellular functions.

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Journal Article•DOI TRP Channels as A Newly Emerging Non-Voltage-Gated Ca2+ Entry Channel Superfamily Ryuji Inoue 31 May 2005-Current Pharmaceutical Design 25 Citations	TRP channels exceptions are two mammalian members that are not Ca2+-permeable cation channels. They are involved in diverse physiological functions and are potential drug therapy targets.
Open access•Journal Article•DOI Editorial: Transient receptor potential (TRP) ion channels in non-excitable cells Mustafa Nazıroğlu, Beatrice Mihaela Radu, Dana Cucu - Show less +2 more 16 May 2023-Frontiers in Physiology	TRP channels are exceptions in non-excitable cells, responsible for various physiological functions like phagocytosis and microglia activation, modulating neuropathic pain, body temperature, and cancer cell migration.
Open access•Book Chapter•DOI Fertility and TRP Channels Ida Björkgren, Polina V. Lishko - Show less +1 more 09 Aug 2017 4 Citations	The exceptions of TRP channels are TRPN channels, exclusively found in invertebrates and fish, while all six subfamilies (TRPV, TRPC, TRPM, TRPA, TRPML, TRPP) are present in mammalian genomes.
Open access•Journal Article•DOI TRP Channels as Emerging Therapeutic Targets in Neurological Disorders 25 Mar 2023-International journal of drug delivery technology	Not addressed in the paper.

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What are invertebrates organisms in which the TRP channels have been explored?5 answersTRP channels in invertebrate organisms have been explored in the following phyla: mollusks, parasitic helminths, choanoflagellates, sponges, Cnidaria, Lophotrochozoa, and arthropods, and schistosomes.

Is beta tubulin 3 involved in TRP channel interaction?5 answersBeta tubulin 3 (β-tubulin 3) is involved in the interaction with TRP channels. The study by Rostovtseva et al. demonstrated that β-tubulin constructs, particularly β3, effectively block the voltage-dependent anion channel (VDAC) of the mitochondrial outer membrane, which is a TRP channel. Additionally, the study by Huai et al. showed that TRPV4, a TRP channel, associates with tubulin beta 5 in transfected cells. These findings suggest that β-tubulin isoforms, including β3 and beta 5, play a role in the interaction with TRP channels.

Does TRPV2 interact with microtubules?5 answersTRPV2 interacts with microtubules. The interaction between TRPV2 and microtubules is important for neurite initiation, extension, and branching events. TRPV2 localizes in specific subcellular regions enriched with filamentous actin, such as growth cones, filopodia, lamellipodia, and neurites. TRPV2 regulates actin cytoskeleton and interacts with soluble actin. The interaction between TRPV2 and microtubules is evolutionary and has functional significance. TRPV2 also interacts with tubulin beta 5, which may play a role in mechanosensation and neuropathic pain. The interaction between TRPV2 and microtubules is mediated through two novel tubulin-binding motifs in the TRPV2 C-terminus.

What are the mechanisms by which TRP channels mediate chemosensation?5 answersTRP channels mediate chemosensation through various mechanisms. They are involved in the detection of chemical stimuli in the oronasal cavities, which contribute to the perception of flavor and trigeminality. TRP channels are activated by chemical compounds, resulting in sensations related to texture, temperature, and pungency. Additionally, TRP channels play a role in nociception and pain, responding to thermal and electrophile stimuli. Some TRP channels are also involved in mechanosensation, responding to changes in membrane stretch and osmotically induced cell swelling or shrinkage. The activation of TRP channels is complex and can be polymodal, with different channels responding to unique forms of activation energy. Overall, TRP channels are crucial in mediating chemosensation by detecting and transducing chemical stimuli into sensory signals.

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