What are the molecular mechanisms involved in uptake and transport of copper in plants?
The molecular mechanisms involved in the uptake and transport of copper (Cu) in plants are complex and crucial for maintaining Cu homeostasis, ensuring plant growth, development, and protection against toxicity. Plants require Cu as an essential micronutrient, acting as a cofactor for various enzymes involved in critical processes such as photosynthesis, respiration, and antioxidant defense. However, excess Cu can be detrimental, necessitating precise regulatory mechanisms for its uptake and transport. Cu uptake in plants is facilitated by high-affinity transporters, notably the COPT (Copper Transporter) family proteins. These transporters are responsible for the uptake of Cu ions from the soil and their distribution within the plant. In Arabidopsis, for example, the COPT family consists of several members localized at both the plasma membrane and internal membranes, indicating a sophisticated system for Cu mobilization. The NRAMP (Natural Resistance-Associated Macrophage Protein) family also plays a role in Cu and other heavy metal strains, suggesting a broader spectrum of metal ion transport and homeostasis. Once inside the plant, Cu is transported to various cellular compartments and integrated into Cu-dependent enzymes and proteins. This transport involves a network of chaperones and additional transport proteins, such as P-type ATPases, which facilitate the movement of Cu ions across cell membranes. The SPL7 transcription factor has been identified as a key regulator of Cu homeostasis, influencing the expression of genes involved in Cu transport and distribution. Mechanisms for detoxification and tolerance against excess Cu involve chelation and sequestration into vacuoles, mediated by metallothioneins, phytochelatins, and specific transporters that prevent toxic concentrations of Cu from accumulating in cellular compartments. Furthermore, the dynamic regulation of COPT transporters, including their degradation and modulation by ubiquitination, plays a critical role in adapting to fluctuating Cu levels, ensuring that uptake and distribution are tightly controlled. In summary, the molecular mechanisms of Cu uptake and transport in plants involve a coordinated network of high-affinity transporters, chaperones, transcription factors, and detoxification pathways, all working together to maintain Cu homeostasis and protect against toxicity.
Answers from top 4 papers
Papers (4) | Insight |
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Plants use transporters for copper uptake and detoxification. They employ chelation and vacuolar sequestration mechanisms, producing metallothioneins and phytochelatins to handle excess copper concentrations. | |
Plants utilize transport proteins like P type ATPases and COPT proteins for copper uptake and distribution, maintaining homeostasis. Chaperones and NRamp genes also play crucial roles in copper transport mechanisms. | |
01 Jan 2022 6 Citations | Copper transport systems in plants play a crucial role in uptake and internal distribution, ensuring plant vigor. Recent research focuses on Cu mobilization, mitochondrial transporters, and signaling pathways. |
Copper transport proteins and chaperone proteins play crucial roles in the uptake and transport of copper in plants, aiding in detoxification and tolerance mechanisms. |