What are the potential therapeutic implications of targeting Sox10 in melanoma treatment?
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Targeting SOX10 in melanoma treatment holds significant therapeutic implications. SOX10-deficient melanoma cells exhibit drug tolerance and resistance to MAPK targeting agents. Loss of SOX10 leads to a tolerant state preluding acquired resistance to BRAF and MEK inhibitors. Additionally, SOX10 expression is inversely correlated with PITX1, a negative regulator of melanoma progression, suggesting a potential therapeutic target. Understanding the role of SOX10 in melanoma plasticity and drug tolerance can guide the development of novel therapeutic strategies. Targeting SOX10-deficient cells with cIAP1/2 inhibitors in combination with BRAF/MEK inhibitors delays acquired resistance, offering a promising approach to combat melanoma progression. This comprehensive approach may enhance treatment efficacy and improve clinical outcomes for melanoma patients.
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3 Citations | Targeting SOX10 in melanoma treatment may be beneficial due to its antagonistic relationship with SOX9, which influences proliferation and invasion, offering a potential therapeutic strategy against melanoma progression. |
| Targeting up-regulated cIAP2 in SOX10-deficient melanoma cells can induce drug tolerance. Inhibiting cIAP1/2 with birinapant delays resistance to BRAF and MEK inhibitors, offering a potential therapeutic strategy. | |
| Targeting SOX10-deficient cells in melanoma may reduce invasive properties, enhance drug sensitivity, delay resistance, and offer a strategy to eliminate drug-tolerant subpopulations for improved treatment outcomes. | |
| Targeting up-regulated cIAP2 in SOX10-deficient melanoma cells can induce drug tolerance. Inhibiting cIAP1/2 with birinapant delays resistance to MAPK inhibitors, suggesting a potential therapeutic strategy for melanoma treatment. |
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