What are the relationship between neurodegenerative diseases and TCA cycle?
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Neurodegenerative diseases (ND) have been linked to alterations in the Tricarboxylic Acid (TCA) cycle, a key metabolic pathway in mitochondria. Studies have shown that neuroinflammatory lesions in the central nervous system can lead to TCA cycle enzyme depletion in neuronal mitochondria, contributing to axonal energy deficits in diseases like multiple sclerosis . Additionally, Curcumae radix extract has been found to increase TCA cycle and Oxidative Phosphorylation (OXPHOS) related genes in mouse brains, suggesting a potential role in modulating brain health and treating ND involving mitochondrial dysfunction . Furthermore, mutations in enzymes of the TCA cycle, such as fumarate hydratase and succinate dehydrogenase, have been associated with predisposition to tumors, highlighting the intricate connection between TCA cycle defects and disease pathogenesis .
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| Papers (4) | Insight |
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148 Citations | Disturbances in the TCA cycle, involving FH and SDH mutations, are linked to tumorigenesis, not neurodegenerative diseases, as per the paper. |
| Not addressed in the paper. | |
| Curcumae radix decreases neurodegenerative markers by activating the TCA cycle, as shown by increased TCA cycle-related mRNA levels and OXPHOS genes in treated groups compared to controls. | |
| Neuroinflammatory lesions in diseases like multiple sclerosis show axonal energy deficiency due to TCA cycle enzyme depletion, suggesting TCA cycle dysfunction's role in neurodegenerative diseases. |
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