M
Mario Kreutzfeldt
Researcher at University of Geneva
Publications - 50
Citations - 2680
Mario Kreutzfeldt is an academic researcher from University of Geneva. The author has contributed to research in topics: Biology & Cytotoxic T cell. The author has an hindex of 19, co-authored 39 publications receiving 2002 citations. Previous affiliations of Mario Kreutzfeldt include World Health Organization & University of Göttingen.
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Journal ArticleDOI
A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis
Ivana Nikić,Doron Merkler,Doron Merkler,Catherine D. Sorbara,Mary Brinkoetter,Mario Kreutzfeldt,Mario Kreutzfeldt,Florence M. Bareyre,Wolfgang Brück,Derron L. Bishop,Thomas Misgeld,Martin Kerschensteiner +11 more
TL;DR: In vivo imaging and pharmacological experiments show that macrophage-derived reactive oxygen and nitrogen species (ROS and RNS) can trigger mitochondrial pathology and initiate FAD, and suggest that inflammatory axon damage might be spontaneously reversible and thus a potential target for therapy.
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The Alarmin Interleukin-33 Drives Protective Antiviral CD8+ T Cell Responses
Weldy V. Bonilla,Anja Fröhlich,Anja Fröhlich,Karin A. Senn,Sandra M. Kallert,Marylise Fernandez,Susan R. Johnson,Mario Kreutzfeldt,Mario Kreutzfeldt,Ahmed N. Hegazy,Ahmed N. Hegazy,Christina Schrick,Christina Schrick,Padraic G. Fallon,Roman Klemenz,Susumu Nakae,Heiko Adler,Doron Merkler,Doron Merkler,Doron Merkler,Max Löhning,Max Löhning,Daniel D. Pinschewer +22 more
TL;DR: It is shown that interleukin-33 (IL-33), an alarmin released from necrotic cells, is necessary for potent CD8+ T cell responses to replicating, prototypic RNA and DNA viruses in mice and showed that endogenous material, independently of pathogen-derived molecules, are also required for antiviral immunity.
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Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection
Karin Steinbach,Ilena Vincenti,Mario Kreutzfeldt,Nicolas Page,Andreas Muschaweckh,Ingrid Wagner,Ingo Drexler,Daniel D. Pinschewer,Thomas Korn,Doron Merkler,Doron Merkler +10 more
TL;DR: During viral infections, brain tissue–resident memory T cells (bTRM) prevent fatal brain infection after acquiring perforin- and IFN-γ–dependent effector functions through a pathway that involves presentation of cognate antigen on MHC-I.
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Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis
Tanja Jürgens,Mehrnoosh Jafari,Mario Kreutzfeldt,Erik Bahn,Wolfgang Brück,Martin Kerschensteiner,Doron Merkler,Doron Merkler,Doron Merkler +8 more
TL;DR: Analysis of several hundred individual neurons revealed a widespread and pronounced loss of dendritic spines in multiple sclerosis cortex that occurs independent of cortical demyelination and axon loss.
Journal ArticleDOI
Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner
Moumita Datta,Ori Staszewski,Elena Raschi,Maximilian Frosch,Nora Hagemeyer,Tuan Leng Tay,Thomas Blank,Mario Kreutzfeldt,Doron Merkler,Stephanie Ziegler-Waldkirch,Patrick Matthias,Melanie Meyer-Luehmann,Marco Prinz +12 more
TL;DR: A role for epigenetic factors that differentially affect microglia development, homeostasis, and disease are reported and could potentially be utilized therapeutically.