What are the specific mechanisms behind the reduction in "Stroke Work" response when perfusion is compromised?
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The specific mechanisms behind the reduction in "Stroke Work" response when perfusion is compromised are not addressed in the provided abstracts.
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| The specific mechanisms behind the reduction in "Stroke Work" response when perfusion is compromised are not mentioned in the provided paper. | |
| The specific mechanisms behind the reduction in "Stroke Work" response when perfusion is compromised are not mentioned in the provided paper. | |
| The specific mechanisms behind the reduction in "Stroke Work" response when perfusion is compromised are not mentioned in the provided paper. | |
06 Feb 2023 | The provided paper does not discuss the specific mechanisms behind the reduction in "Stroke Work" response when perfusion is compromised. |
| The provided paper does not discuss the specific mechanisms behind the reduction in "Stroke Work" response when perfusion is compromised. |
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How does perfusion effect mechanical properties of in the brain tissue?5 answersPerfusion does not significantly affect the stiffness of living cortical tissue in the brain. However, the viscoelastic properties of the brain, which reflect tissue architecture at multiple length scales, are influenced by perfusion. The mechanical properties of brain tissue, such as Young's modulus and Poisson's ratio, can be affected by perfusion. In an experimental model using bovine brains, perfusion increased the mean value of the Young's modulus compared to nonperfused brains. Additionally, changes in mechanical properties of brain tissue due to the loss of perfusion can be characterized by changes in the apparent stress-strain curve. Tissue viscoelasticity also increases the sensitivity of the system to perfusion pressure changes. Therefore, while perfusion may not directly affect the stiffness of living cortical tissue, it can influence the viscoelastic properties and mechanical response of brain tissue.
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How to reduce pre-hospital delay in stroke?5 answersTo reduce pre-hospital delay in stroke, several strategies can be implemented. First, improving family function and reducing stroke-related stigma can help in reducing pre-hospital delay among patients with recurrent stroke. Second, increasing public awareness through various health campaigns can play a crucial role in shortening pre-hospital delay and decision delay. Third, enhancing the recognition of stroke symptoms by Emergency Medical Service (EMS) dispatchers can lead to shorter pre-hospital delay and higher rates of revascularization treatment. Finally, addressing decision delay as a component of pre-hospital delay is important, and factors such as prior stroke knowledge, perceived cause and severity of symptoms, and advice from bystanders can help in shortening decision delay. By implementing these strategies, it is possible to reduce pre-hospital delay in stroke and improve patient outcomes.
Why does low blood pressure cause impaired tissue perfusion?2 answersLow blood pressure can cause impaired tissue perfusion due to the reduced driving force for blood flow through the microcirculation. The microcirculation, which includes the smallest arteries, arterioles, capillaries, and venules, is responsible for the exchange of gases, nutrients, and metabolites between the blood and tissues. Inadequate perfusion through the microcirculatory network can lead to tissue and organ dysfunction associated with chronic conditions such as hypertension, obesity, and diabetes mellitus. In hypertension, structural alterations in the microcirculation, including remodeling of microvascular vessels and capillary rarefaction, can further contribute to impaired tissue perfusion. These changes result in a reduction in the number of arterioles or capillaries in a given vascular bed, leading to decreased tissue perfusion and increased cardiovascular risk. Therefore, low blood pressure can negatively impact tissue perfusion by compromising the function and structure of the microcirculation.
What are the most common intraoperative complications during stroke surgery?5 answersPerioperative stroke is a potentially devastating complication with an incidence of 0.1–0.6% in non-cardiac surgery. Stroke in the perioperative setting is associated with an adjusted 8-fold increase in mortality. Patients undergoing cardiac and vascular operations have a higher risk of perioperative stroke compared to uncomplicated orthopedic and general procedures. Preoperative optimization for preexisting risk factors may reduce the rate of perioperative stroke. Prompt, early management can improve patient outcomes. Recognition of the incidence, risk factors, and causes of perioperative stroke may lead to prevention and proper management. Perioperative stroke is associated with considerable morbidity and mortality. Stroke recognition and diagnosis are challenging perioperatively, and surgical patients receive therapeutic interventions less frequently compared with stroke patients in the outpatient setting. Patients who have had a stroke are susceptible to many complications. Cardiac complications, pneumonias, venous thromboembolism, fever, pain, dysphagia, incontinence, and depression are particularly common after a stroke and usually require specific interventions for their prevention and treatment.
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