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What carbonic anhydrases performuoti ph regulation at ph 6?

Intracellular pH

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Carbonic anhydrases play a crucial role in pH regulation at pH 6. In the context of the heart, membrane-bound carbonic anhydrase (CA) facilitates the hydration-dehydration of CO2-H2CO3, enhancing CO2 transfer and contributing significantly to intracellular pH recovery after myocardial ischemia . Additionally, carbonic anhydrase IX (CAIX) is highlighted for its role in regulating tumor pH, making it a potential target for cancer therapy . In rapidly proliferating cells, CA IX enhances acid-regulatory capacity, aiding in pH maintenance . Moreover, in the liver, carbonic anhydrase activity influences urea synthesis, with acetazolamide inhibiting this process at subphysiological HCO3- and CO2 concentrations . Overall, carbonic anhydrases, including CA and CAIX, are essential for pH regulation at pH 6 in various physiological and pathological contexts.

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Open access•Dissertation Assessment of enhanced carbon dioxide absorption in water - The impact of carbonic anhydrase and pH regulation Johanna Beiron 01 Jan 2017	Not addressed in the paper.
Open access•Journal Article•DOI Hepatic urea synthesis and pH regulation: role of CO2, HCO3−, pH and the activity of carbonic anhydrase Dieter Häussinger, Wolfgang Gerok - Show less +1 more 01 Oct 1985-FEBS Journal 91 Citations	Not addressed in the paper.
Open access•Journal Article•DOI New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation Pawel Swietach, Alzbeta Hulikova, Richard D. Vaughan-Jones, Adrian L. Harris - Show less +3 more 16 Dec 2010-Oncogene 216 Citations	Carbonic anhydrase IX (CAIX) plays a role in tumor pH regulation, but the specific carbonic anhydrases involved in pH regulation at pH 6 are not addressed in the paper.
Open access•Journal Article•DOI Carbonic anhydrase IX is a critical determinant of pulmonary microvascular endothelial cell pH regulation and angiogenesis during acidosis. Ji Young Lee, Mikhail Alexeyev, Natalya Kozhukhar, Viktoriya Pastukh, Roderica White, Troy Stevens - Show less +5 more 01 Jul 2018-American Journal of Physiology-lung Cellular and Molecular Physiology 17 Citations	Carbonic anhydrase IX (CA IX) is the critical determinant of pulmonary microvascular endothelial cell pH regulation at pH 6, aiding in angiogenesis during acidosis.
Journal Article•DOI Carbonic anhydrase and cardiac pH regulation Jamie I. Vandenberg, ND Carter, Hwl Bethell, Antal Nógrádi, Y. Ridderstrale, J C Metcalfe, Andrew A. Grace - Show less +6 more 01 Dec 1996-American Journal of Physiology-cell Physiology 38 Citations	Not addressed in the paper.

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Association between CArbonic anhydrase II INHIBITORwith WNT Signaling pathway?5 answersThe association between carbonic anhydrase II (CAII) inhibitor and the WNT signaling pathway is not directly addressed in the provided abstracts. However, the abstracts do mention the involvement of other carbonic anhydrases (CA4 and CAIII) in the WNT signaling pathway. CA4 is identified as a novel tumor suppressor in colorectal cancer (CRC) through the inhibition of the WNT signaling pathway by targeting the WTAP-WT1-TBL1 axis. CAIII is highly expressed in osteocytes and is regulated by parathyroid hormone, protecting osteocytes from oxidative stress. While the abstracts provide insights into the role of carbonic anhydrases in cancer and bone biology, they do not specifically address the association between CAII inhibitor and the WNT signaling pathway. Further research may be needed to explore this specific association.

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Do carbonic anhydrase inhibitors effect thyroid ?5 answersCarbonic anhydrase inhibitors have been found to have an effect on the thyroid. In patients with thyrotoxicosis, the concentration of erythrocyte carbonic anhydrase-I (C.A.I.) was found to be below the normal range. Additionally, in patients taking oral contraceptives, a low erythrocyte-C.A.I. concentration was noted, particularly among those taking low-estrogen contraceptives. These findings suggest that erythrocyte-C.A.I. estimation could serve as a rapid screening test for thyrotoxicosis.

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