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What effect does PTZ have on serotonin receptors?

5-HT5A receptor

G protein-coupled receptor

Seizure threshold

Bacopa monnieri

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PTZ, or pentylenetetrazole, induces changes in serotonin (5-HT) receptors. Studies have shown that PTZ administration leads to alterations in serotonin levels in various brain regions. Specifically, PTZ-induced epilepsy results in a significant decrease in serotonin levels in different brain regions. Furthermore, the interaction between serotonin receptors and other neurotransmitters like dopamine and noradrenaline is modulated during the postictal stage, affecting motor deficits. These findings suggest that PTZ impacts serotonin receptors by influencing their levels and interactions with other neurotransmitters, highlighting the complex role of serotonin in the context of seizures and related neurological processes.

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Open access•Journal Article•DOI Effect of postictal process in motor deficit and monoaminergic concentration in hippocampus, cerebellum, and cortex Alberto Avila-Luna, Antonio Bueno-Nava, José Luis Cortes-Altamirano, Samuel Reyes-Long, Cindy Bandala, Alfonso Alfaro-Rodríguez - Show less +5 more 23 Oct 2019-Salud Mental	PTZ induces an increase in total 5-HT levels in the hippocampus, cerebellum, and cortex, affecting serotonin receptors and potentially influencing motor deficits during the postictal stage.
Journal Article•DOI Anticonvulsant effect of Bacopa monnieri extracts on Catecholamine metabolism during PTZ-induced Epilepsy in different brain regions of Albino Rat E. Komali, Ch. Venkataramaiah, Wudayagiri Rajendra - Show less +2 more 30 Apr 2018-Research Journal of Pharmacy and Technology 4 Citations	Not addressed in the paper.
Open access•Journal Article•DOI The effect of sertraline and 8-OH-DPAT on the PTZ_induced seizure threshold: Role of the nitrergic system. Azhdar Heydari, Shima Davoudi - Show less +1 more 01 Feb 2017-Seizure-european Journal of Epilepsy 18 Citations	Not addressed in the paper.
Open access•Journal Article•DOI Zinc Is Involved in Depression by Modulating G Protein-Coupled Receptor Heterodimerization Mercè Tena-Campos, Eva Ramon, Cecylia S. Lupala, Juan J. Perez, Karl-W. Koch, Pere Garriga - Show less +5 more 01 Apr 2016-Molecular Neurobiology 22 Citations	Not addressed in the paper.
Journal Article•DOI Loss-of-function of PTPR γ and ζ, observed in sporadic schizophrenia, causes brain region-specific deregulation of monoamine levels and altered behavior in mice Arnaud Cressant, Véronique Dubreuil, Véronique Dubreuil, Jing Kong, Thorsten M. Kranz, Françoise Lazarini, Jean-Marie Launay, Jacques Callebert, Jan Sap, Dolores Malaspina, Sylvie Granon, Sheila Harroch, Sheila Harroch - Show less +12 more 06 Feb 2017-Psychopharmacology 18 Citations	Not addressed in the paper.

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