What factors contribute to the instability of pharmaceutical suspensions?
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The instability of pharmaceutical suspensions can be influenced by various factors. Factors such as solid phase particle size, liquid phase density, and viscosity play a role in suspension stability prediction . Additionally, stressors like cold and thermal denaturation conditions, pH variations, environmental agitation, and storage container materials can impact the stability of protein and peptide drugs used in pharmaceuticals . Furthermore, the particle size and surface roughness of spray-dried particles can affect the colloidal stability of pressurized pharmaceutical suspensions, with surface modification techniques showing promise in improving stability . It is crucial to conduct stability studies using methods like visual inspection, pH monitoring, and HPLC to ensure the efficacy of extemporaneous preparations within recommended timeframes .
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28 Citations | Particle surface roughness plays a crucial role in the instability of pharmaceutical suspensions. Higher surface roughness reduces particle cohesion, enhancing colloidal stability in pressurized suspensions. |
| Factors contributing to instability of pharmaceutical suspensions include cold/thermal denaturation, pH variations, agitation, and container interactions. Strategies like genetic engineering, additives, and fusion methods help stabilize proteins. | |
| Factors contributing to instability of pharmaceutical suspensions include caking, pH and color changes, crystal growth, microbial growth, rapid settling of particles, and decrease in drug potency. | |
| Factors contributing to the instability of pharmaceutical suspensions include light exposure, absence of stabilizers, and storage conditions. Stability testing is crucial for ensuring pharmaceutical product quality and efficacy. | |
Open access•Journal Article 5 Citations | Factors contributing to instability of pharmaceutical suspensions include particle size, liquid density, viscosity, and flocculation. Controlled flocculation of particles, like bismuth subnitrate, can prevent sediment formation. |
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