What is adductomics?
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Adductomics is a cutting-edge field that involves the comprehensive analysis of chemical adducts on various biomolecules like albumin, hemoglobin, and DNA to understand the impact of chemical exposures on health. This approach utilizes advanced mass spectrometry techniques, such as ultra-high pressure liquid chromatography coupled with nanoelectrospray tandem mass spectrometry, to identify and quantify these adducts. By studying adducts induced by both endogenous and exogenous sources, adductomics plays a crucial role in elucidating the molecular mechanisms underlying diseases like cancer. The ultimate goal of adductomics is to establish a cause-and-effect relationship between chemical exposure and illness, offering valuable insights into toxicant exposure levels and potential disease biomarkers.
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24 Jan 2022 | Adductomics is a new research field utilizing UHPLC-HRMS to screen for unknown DNA adducts, aiding in identifying genotoxic molecules that can initiate cancer by modifying DNA. |
24 Jan 2022 | Adductomics is a novel research field utilizing high-resolution mass spectrometry to screen for unknown DNA adducts, which are covalent modifications of DNA by genotoxic molecules from various sources. |
| Adductomics is molecular epidemiology comparing chemical adduct levels in healthy vs. exposed individuals to establish links between chemical exposure and illness, aiding in biomarker discovery for diseases. | |
| Adductomics is a field utilizing mass spectrometry to comprehensively identify and quantify DNA adducts, crucial for understanding their roles in human diseases and biological processes. |
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