What is the advantage of using the combination of gelatin and chitosan in bone tissue engineering using electrospinning?
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The combination of gelatin and chitosan in bone tissue engineering using electrospinning offers several advantages. Gelatin and chitosan are natural biopolymers that closely mimic the extracellular matrix of natural bone, providing structural and biochemical cues for bone formation . When combined in nanofibrous scaffolds, they exhibit properties such as high surface-area-to-volume ratio, morphological resemblance to the extracellular matrix, and stability, which are crucial for effective bone tissue engineering . Additionally, the incorporation of monetite nanoparticles into gelatin scaffolds enhances their physicochemical, mechanical, and biological properties, leading to improved cell adhesion, proliferation, and differentiation, ultimately promoting bone regeneration . This combination shows promise in creating biosynthetic bone grafts that can aid in restoring fractured bones and preventing amputations, thus reducing expenses associated with bone injuries .
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1 Citations | The combination of gelatin and chitosan in electrospun scaffolds enhances cell viability, proliferation, and attachment of osteoblasts, indicating potential for bone tissue engineering. |
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| The combination of gelatin and chitosan in bone tissue engineering enhances cell adhesion, proliferation, and differentiation, creating a conducive microenvironment for osteoblast lineage development in contact with the scaffold. | |
| Combining gelatin and chitosan in electrospun nanofibers for bone tissue engineering offers enhanced structural and biochemical cues, aiding in bone formation and defect treatment. |
Related Questions
What are the studies used gelatin in bone tissue engineering using electrospinning?5 answersGelatin has been extensively studied in bone tissue engineering using electrospinning. Studies have focused on creating gelatin-based scaffolds with enhanced properties for bone regeneration. These scaffolds often incorporate additional materials like chitosan, monetite, and TiO2 nanoparticles to improve mechanical strength, mineralization ability, and cellular response. The electrospun gelatin scaffolds have shown promising results in terms of mimicking the extracellular matrix of natural bone, enhancing osteogenic properties, and supporting cell adhesion, proliferation, and differentiation. The combination of gelatin with various additives has demonstrated potential for use in regenerative dentistry and bone tissue engineering, highlighting the versatility and effectiveness of gelatin-based electrospun scaffolds in promoting bone regeneration and repair.
Does chitosan has osteoconductive and osteoinductive potential on bone?5 answersChitosan has demonstrated osteoconductive and osteoinductive potential on bone regeneration. Studies have shown that chitosan-based scaffolds, when combined with materials like hydroxyapatite, silica, and tricalcium phosphate, enhance bone regeneration by providing structural support, bioactivity, and stimulating cell differentiation. Furthermore, the incorporation of growth factors such as BMP-2 and P28 into chitosan scaffolds has been found to promote osteogenic activity, leading to increased bone mineral density and volume in bone defect models. Additionally, the use of chitosan in nanoformulations with metformin has shown promising results in promoting osteogenesis and bone tissue regeneration in vitro. Overall, chitosan's combination with various biomaterials and growth factors highlights its potential as an effective osteoconductive and osteoinductive agent for bone healing applications.
What are the potential benefits of using nanomaterials in bone tissue engineering?5 answersNanomaterials offer significant advantages in bone tissue engineering due to their unique properties. They can mimic bone characteristics, enhance bioactivity, and provide tailored physicochemical features for better cell interactions. Nanomaterials like tubular nanomaterials and calcium phosphate-based biomaterials show promise in bone regeneration by offering high surface area, versatile chemistry, and excellent biocompatibility. Additionally, nanomaterials can be functionalized with various substances, making them versatile for drug delivery, cancer therapy, and bioimaging applications. Their ability to create suitable microenvironments for regulating therapeutic effects and their potential to mimic the hierarchical architecture of natural bone make nanomaterials valuable for innovative bone injury repair strategies.
What are the properties of edible films made from gelatin and chitosan?4 answersEdible films made from gelatin and chitosan have several desirable properties. They are biocompatible, biodegradable, renewable, non-toxic, and have good gas barrier properties. However, gelatin and chitosan have low physicochemical stability and poor mechanical properties. To overcome these limitations, dialdehyde chitosan can be incorporated as a cross-linking agent for gelatin, resulting in improved mechanical strength and swelling properties of the films. Gelatin-based films incorporating squid pen chitosan obtained by high hydrostatic pressure (HHP chitosan) also show enhanced mechanical and moisture barrier properties. Additionally, gelatin/chitosan films containing eugenol and oregano essential oil exhibit antimicrobial activity against Staphylococcus aureus and Escherichia coli, making them suitable for food preservation. Furthermore, films made from a combination of gelatin and chitosan from A.stellatus n.cyrenisis Berg skin waste have improved mechanical attributes and antibacterial activity, making them suitable for food packaging.
Why chitosan is used in tissue engineering?5 answersChitosan is used in tissue engineering because of its good biocompatibility, biodegradability, antioxidant effect, anti-inflammatory activity, and broad-spectrum antimicrobial property. It can be chemically modified to improve its physicochemical properties and biological functions. Chitosan-based hydrogels can be constructed as composite systems to achieve local sequential delivery of drugs or bioactive factors, facilitating the regeneration of defective tissues. Chitosan hydrogels can also serve as suitable scaffold biomaterials when transplanted with stem cells, growth factors, or exosomes, promoting the regeneration of oral soft and hard tissues. Additionally, chitosan-containing scaffolds have unique antimicrobial activity, biodegradability, and biocompatibility, making them suitable for various biomedical applications, including drug delivery, regenerative medicine, and tissue engineering. Chitosan hybrid materials, when combined with nanostructured scaffolds, have the potential for long-term therapeutic use and drug release for tissue fixation and regeneration. Chitosan-based porous tissue scaffolds can be fabricated with additional functional properties, such as drug release capabilities, and have the potential for clinical application in bone-cartilage interface regeneration. Chitosan-based composites filled with functional agents like reduced graphene oxide (rGO) and tricalcium phosphate (TCP) can enhance the morphological, electrically conductive, and mechanical characteristics of the composites, making them suitable for osteogenesis purposes.
Does electrospinning of chitosan depend on its molecular weight?5 answersElectrospinning of chitosan does depend on its molecular weight. Blending chitosan with other polymers such as polyvinyl alcohol (PVA), polycaprolactone (PCL), and polylactic acid (PLA) enhances its spinnability and produces nanofibers with better quality. The viscoelastic properties of chitosan solutions, influenced by molecular weight, concentration, and ratio of chitosan and additive poly(ethylene oxide), affect the electrohydrodynamic jet behavior and resulting fiber morphologies. The temperature of chitosan solutions and the chamber also play a critical role in the electrospinning process, affecting the morphology of the nanofibers. Additionally, the conductivity of chitosan solutions in different organic acids can influence the electrospinning process, but there is no direct correlation between solution conductivity and electrospinnability.