What is the current state of research on the synthesis and characterization of maghemite nanoparticles?4 answersCurrent research on maghemite nanoparticles focuses on various synthesis methods and their characterization for different applications. Studies have explored hydrothermal synthesis using FeCl2·4H2O and FeCl3·6H2O precursors at different temperatures, sonochemical synthesis with FeSO4·7H2O for magnetic hyperthermia treatment, incorporation of maghemite in carboxymethyl cellulose for multifunctional nanocomposite films, and efficient synthesis of maghemite from magnetite for gas sensing applications. These studies employ techniques like X-ray diffraction, scanning electron microscopy, and Fourier-transform infrared spectroscopy to characterize the structural, morphological, and chemical properties of the synthesized maghemite nanoparticles. The research highlights the potential of maghemite nanoparticles in various fields such as renewable energy, medicine, and gas sensing applications.
Is there paper using nanoluc to detect antibodies od sars-cov2?5 answersYes, a research paper by Paula Segovia-de los Santos et al. developed a method using a nanobody-NanoLuc luciferase chimeric tracer to detect antibodies against SARS-CoV-2 nucleocapsid protein with high sensitivity. This approach significantly improved diagnostic performance, with a detection limit of 61 pg/mL and a specificity of 100%. The study utilized this luminescent assay to evaluate 115 nasopharyngeal swab samples, demonstrating its effectiveness in detecting antibodies against SARS-CoV-2. The nanobody-NanoLuc luciferase chimeric tracer provided enhanced sensitivity and diagnostic value, making it a valuable tool for detecting SARS-CoV-2 antibodies in clinical samples.
What are the current scientific studies investigating the effectiveness of electrical stimulation as a treatment for COVID-19?5 answersCurrent scientific studies are exploring the efficacy of electrical stimulation as a treatment for various symptoms associated with COVID-19. One study focused on lower extremity electrical stimulation (E-Stim) to address muscle deconditioning in post-acute sequelae of Sars‐CoV‐2 (PASC) patients, showing improvements in muscle perfusion and endurance. Another study investigated transcranial direct current stimulation (tDCS) for cognitive deficits and mood disorders in long COVID patients, highlighting potential benefits in improving cognition and mood. Additionally, acupoint stimulation therapy, a form of traditional Chinese medicine, is being considered for treating long COVID-related symptoms like palpitations, dyspnea, cognitive impairment, anxiety, and depression. Furthermore, a study examined the use of pudendal nerve electrical stimulation to treat erectile dysfunction associated with COVID-19, demonstrating significant improvements in erectile function and quality of life satisfaction.
How to use magnetic nanoparticles?3 answersMagnetic nanoparticles can be used in various applications such as drug delivery, magnetic hyperthermia, magnetic resonance imaging (MRI), magnetic particle imaging, biosensors, tissue engineering, biosynthesis, catalysis, electronic and microwave-absorbing materials, and environmental treatment. They have high surface area, size-dependent superparamagnetic properties, precision tunability, and easy surface modification, making them versatile for different purposes. The chemical coprecipitation method is commonly used for their preparation due to its simplicity, low cost, and easily-controlled operating conditions. Magnetic nanoparticles can be coated with human serum albumin or polyethylene glycol to enhance biocompatibility and minimize potential toxicity when used in vivo. They can interact with lipid membranes, potentially leading to the appearance of conducting pores and increasing the integral conductivity of the membranes. In environmental science and engineering, magnetic nanoparticles have been used for the purification of whey, removal of heavy toxic metals, and photocatalytic degradation of pollutants in water.
What is new research of plasma corona and nanoparticles?5 answersRecent research on plasma corona and nanoparticles has revealed several new findings. One study investigated the combination of personalized protein corona and N-glycosylation profiling for disease diagnosis. Another study focused on the formation, detection, and characterization of protein corona on biologically produced gold nanoparticles. A comprehensive quantitative characterization of the corona formed on silver nanoparticles was also conducted, providing insights into the protein composition and structural properties. Additionally, the regulation of protein corona formation on phosphomolybdate-based nanoparticles through the introduction of a zwitterionic polymer was explored. Finally, a systematic study of the protein corona formed from human plasma on silver and gold nanoparticles with different surface modifications was conducted, highlighting the role of surface charge and core in determining the corona compositions. These studies contribute to our understanding of the interactions between nanoparticles and plasma, with implications for various applications in nanomedicine.
What are the main challenges in the development and use of magnetic nanoparticles?4 answersThe main challenges in the development and use of magnetic nanoparticles include the need for a deeper understanding of their impact on complex biological systems. There is a lack of selective interaction with neoplastic cells, which reduces the effectiveness of cancer therapies. The size, concentration, and external magnetic field intensity affect the evolution of chain structures and collective magnetic features of magnetic nanoparticles. Iron-oxide-based magnetic nanoparticles face limitations such as ineffective spatial guidance, poor colloidal stability, low drug loading, and inadequate drug release. In the treatment of lung infections, challenges include ensuring sufficient therapeutic dosages at the primary target site and minimizing the risks of systemic toxicity.