What is the current understanding of the effectiveness of doxycycline in treating dengue fever in animals?
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Current research suggests that doxycycline shows promise in treating dengue fever in humans by reducing bleeding manifestations, mortality rates, and pro-inflammatory cytokine levels . Additionally, doxycycline exhibits antiviral activity against dengue virus replication in vitro, inhibiting viral entry and post-infection replication of all four dengue serotypes . Furthermore, studies comparing doxycycline and tetracycline in patients with dengue fever or dengue hemorrhagic fever indicate that doxycycline is more effective in modulating cytokine and cytokine receptor/antagonist levels, leading to a significant decline in cytokine levels and a rise in IL-1Ra levels . These findings collectively suggest that doxycycline may have a beneficial impact on dengue fever outcomes in humans, warranting further experimental and clinical investigations.
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76 Citations | Doxycycline inhibits dengue virus replication in vitro, showing potential as a treatment option. Further research is needed to explore its effectiveness in treating dengue fever in animals. |
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