H
Hussin A. Rothan
Researcher at Florida State University College of Arts and Sciences
Publications - 74
Citations - 6142
Hussin A. Rothan is an academic researcher from Florida State University College of Arts and Sciences. The author has contributed to research in topics: Dengue virus & Virus. The author has an hindex of 24, co-authored 71 publications receiving 4310 citations. Previous affiliations of Hussin A. Rothan include University of Malaya & International Medical University.
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Journal ArticleDOI
The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak.
TL;DR: The symptoms, epidemiology, transmission, pathogenesis, phylogenetic analysis and future directions to control the spread of this fatal disease are highlighted.
Journal ArticleDOI
Neuroinvasion and Encephalitis Following Intranasal Inoculation of SARS-CoV-2 in K18-hACE2 Mice.
Pratima Kumari,Hussin A. Rothan,Janhavi P Natekar,Shannon Stone,Heather Pathak,Philip G Strate,Komal Arora,Margo A. Brinton,Mukesh Kumar +8 more
TL;DR: In this article, the authors demonstrate that SARS-CoV-2 neuroinvasion and encephalitis is associated with mortality in K18-hACE2 mice with 105 plaque-forming units.
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The FDA-approved gold drug auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells.
TL;DR: Data indicate that auranofin could be a useful drug to limit SARS-CoV-2 infection and associated lung injury due to its antiviral, anti-inflammatory and anti-reactive oxygen species (ROS) properties.
Posted ContentDOI
Neuroinvasion and encephalitis following intranasal inoculation of SARS-CoV-2 in K18-hACE2 mice
Pratima Kumari,Hussin A. Rothan,Janhavi P Natekar,Shannon Stone,Heather Pathak,Philip G Strate,Komal Arora,Margo A. Brinton,Mukesh Kumar +8 more
TL;DR: The data indicate that direct infection of CNS cells together with the induced inflammatory response in the brain resulted in the severe disease observed in SARS-CoV-2-infected K18-hACE2 mice.
Journal ArticleDOI
A Combination of Doxycycline and Ribavirin Alleviated Chikungunya Infection
Hussin A. Rothan,Hirbod Bahrani,Zulqarnain Mohamed,Teow Chong Teoh,Esaki M. Shankar,Noorsaadah Abd Rahman,Rohana Yusof +6 more
TL;DR: Assays using mice as animal models revealed that DOXY+RIBA effectively inhibited CHIKV replication and attenuated its infectivity in vivo, and TETRA derivatives showed higher inhibition of viral infectivity and entry than RIBA.