What is the desired maintained time of nanoparticles in cells for drug delivery?
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The desired maintained time of nanoparticles in cells for drug delivery varies depending on the specific drug release requirements. Studies have shown that sustained drug release for a prolonged duration is a desired feature of modern drugs, with examples of nanoparticles achieving this goal. Nanoparticles can enhance and sustain drug delivery inside cells, with some formulations demonstrating sustained release over a 15-day period in vitro. Additionally, the development of a continuous flow microreactor and an in vitro microfluidic drug delivery model have been introduced to analyze real-time drug efficacy and cytotoxic effects, showcasing the potential for on-demand screening of cancer drugs. These findings highlight the importance of maintaining nanoparticles in cells for extended periods to achieve sustained and effective drug delivery.
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| Papers (5) | Insight |
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98 Citations | The nanoparticles demonstrated sustained release of doxorubicin over a 15-day period in vitro, indicating the desired maintained time for drug delivery into cells. |
| Nanoparticles for drug delivery aim to extend circulation time by overcoming barriers, with some designs projecting a 100-hour half-life extension for therapeutic proteins, enhancing drug efficacy. | |
| The nanoparticles are designed for real-time drug delivery into apoptotic cancer cells, with a focus on efficient drug transport kinetics rather than a specific desired maintenance time in cells. | |
37 Citations | The sustained drug release achieved by double-loaded self-decomposable SiO₂ nanoparticles demonstrated a Tmax of about 8 hours in blood circulation, with a plasma elimination half-life of approximately 28 hours. |
3 Citations | The desired maintained time of nanoparticles in cells for drug delivery is typically 48 hours, as it mimics the residence time of nanoparticles in vivo, preventing aggregation and ensuring efficacy. |
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