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What is the diagnostic performance of procalcitonin for diagnosing bacterial infections in patients with cirrhosis?

Spontaneous bacterial peritonitis

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Procalcitonin (PCT) demonstrates good diagnostic performance for identifying bacterial infections in patients with cirrhosis. Studies show that elevated PCT levels are associated with infections in cirrhotic patients, with a sensitivity of 80.3% and specificity of 86.6% at a cut-off of ≥0.9 ng/mL . Additionally, in patients with spontaneous bacterial peritonitis (SBP), ascitic PCT levels have shown higher diagnostic accuracy compared to C-reactive protein (CRP), with an area under the curve (AUC) of 0.751 at a cut-off of ≥1 ng/mL . Serum PCT levels have also been found to be significantly elevated in SBP patients, aiding in the diagnosis of this serious complication in cirrhosis . Overall, PCT levels, both in serum and ascitic fluid, serve as valuable markers for the early detection of bacterial infections in cirrhotic patients, contributing to improved diagnostic accuracy and timely intervention.

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Journal Article•DOI Diagnostic role of procalcitonin serum level in hepatitis C virus-infected patients with spontaneous bacterial peritonitis Mohamed El Hasafy, Dalal M. El Kaffash, M.O. Shater, N. Attia - Show less +3 more 01 Apr 2022-Menoufia Medical Journal	Serum procalcitonin levels are valuable for diagnosing spontaneous bacterial peritonitis in cirrhotic patients, with a cutoff value of 0.17 ng/ml showing good diagnostic certainty for culture-positive or negative SBP.
Open access•Journal Article•DOI Impact of Serum and Ascitic Fluid Procalcitonin on Diagnosis and Outcome of Patients with Spontaneous Bacterial Peritonitis Ahmed S.M. Saleh, Ahmed Gamal Khafagy, Ahmed Shawki Hasan, Ayman N. Menessy, Salah Rozaik - Show less +4 more 01 Oct 2022-The Egyptian Journal of Hospital Medicine	Serum and ascitic fluid procalcitonin levels are significantly high in spontaneous bacterial peritonitis (SBP) patients with high specificity, sensitivity, positive and negative predictive values, aiding in diagnosing bacterial infections in cirrhotic patients.
Open access•Journal Article•DOI Procalcitonin and C-reactive protein in the diagnosis of spontaneous bacterial peritonitis 01 Oct 2022-Translational Gastroenterology and Hepatology 2 Citations	Procalcitonin shows promise as a non-invasive marker for diagnosing spontaneous bacterial peritonitis in cirrhotic patients, aiding in timely antibiotic initiation for improved outcomes.
Open access•Journal Article•DOI MCP1, CRP and Procalcitonin as Novel Diagnostic Markers in Cirrhotic Patients with Spontaneous Bacterial Peritonitis Amal Ahmed Mohamed, Wafaa Salah, Mohamed B Hassan, Hala H. Eldeeb, Ahmed Sobhy Adaroas, Rania Abdelmonem Khattab, Heba M. Abostate, Moataz Yousry Soliman, Eslam Habba, Sherief Abd-Elsalam, Yousry Esam-Eldin Abo-Amer - Show less +10 more 23 Aug 2022-The Open Biomarkers Journal	Procalcitonin has a diagnostic performance with sensitivity of 65.4% and specificity of 75.5% at a cut-off of ≥1 ng/ml for diagnosing spontaneous bacterial peritonitis in cirrhotic patients.
Open access•Journal Article•DOI The Role of Presepsin and Procalcitonin in Early Diagnosis of Bacterial Infections in Cirrhotic Patients with Acute-on-Chronic Liver Failure R. Igna, Irina Girleanu, Camelia Cojocariu, Laura Huiban, Cristina Maria Muzica, Ana-Maria Singeap, Catalin Sfarti, Stefan Chiriac, Oana Petrea, Sebastian Zenovia, Robert Nastasa, Tudor Cuciureanu, R. Stafie, Ermina Stratina, A. Rotaru, Carol Stanciu, Mihaela Blaj, Anca Trifan - Show less +17 more 01 Sep 2022-Stomatology 1 Citations	Procalcitonin has a sensitivity of 80.3% and specificity of 86.6% with a cut-off value of 0.9 ng/mL for diagnosing bacterial infections in cirrhotic patients.

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