What is the difference in tumour core stiffness compared with periphery?
Best insight from top research papers
The stiffness of tumor cores compared to the periphery varies significantly. Research has shown that in glioblastomas, the median stiffness (G') and viscosity (G'') in the contrast-enhancing tumor core were notably lower than in normal-appearing white matter, with a 15% and 39% decrease, respectively . Additionally, the tumor core exhibited a 53% lower fractional anisotropy (FA) and significantly higher apparent diffusion coefficient (ADC) and cerebral blood flow (CBF) compared to normal tissue . This difference in stiffness between the core and periphery of tumors plays a crucial role in tumor behavior, influencing invasiveness and response to therapy .
Answers from top 5 papers
More filters
| Papers (5) | Insight |
|---|---|
Open access•Dissertation 01 Nov 2014 5 Citations | The research paper does not address the difference in tumour core stiffness compared with the periphery. |
| Tumour core stiffness is lower than periphery in glioblastomas, with stiffness and viscosity reduced in tumour regions compared to healthy tissue. | |
131 Citations | There is no significant difference in stiffness between the central and peripheral regions of cancer cells, as determined by AFM indentation tests. |
| Tumor stiffness influences metastasis by upregulating N-Cadherin in endothelial cells, aiding cancer cell dissemination. The core stiffness is higher than the periphery, impacting interactions with surrounding cells. | |
177 Citations | Tumour core stiffness is higher due to increased matrix deposition, cellularity, and pressure buildup, impacting invasiveness and therapy efficacy, compared to the softer periphery. |
Related Questions
How posture affects arterial stiffness measurement?5 answersPosture significantly impacts arterial stiffness measurement. Studies show that assessing pulse wave velocity (PWV) in different body positions alters stiffness readings. When transitioning from supine to semi-Fowler's position or head-up tilt, carotid-femoral PWV (cfPWV) increases notably, indicating heightened arterial stiffness. Additionally, variations in posture affect central blood pressure and PWV values differently. While brachial pulse wave analysis remains stable across positions, finger-to-toe PWV notably rises with postural changes, suggesting a potential link between hydrostatic pressure and arterial stiffness dynamics. These findings emphasize the importance of considering body position during arterial stiffness assessments, with supine positioning recommended for accurate measurements, or alternatively, knee bend and slight incline as viable options if supine posture is not feasible.
How cell morphology and stiffness?5 answersCell morphology and stiffness are intricately linked in influencing cell behavior and differentiation. Studies have shown that cell morphology can override the effects of matrix stiffness on mesenchymal stem cell (MSC) differentiation by regulating the activity of YAP/TAZ transcription factors. Additionally, cell spreading area and hydrogel stiffness synergistically affect adipogenic differentiation of human bone-marrow-derived MSCs, while cell elongation does not have a significant impact. Furthermore, changes in cell stiffness, measured by elasticity modulus, can be induced by oxidative stress, leading to alterations in cell biomechanical behavior. These findings highlight the importance of considering both cell morphology and stiffness in understanding how cells respond to their mechanical microenvironment and regulate their differentiation processes.
What are the molecular mechanisms underlying the signaling differences between the tumor core and periphery?4 answersThe molecular mechanisms underlying the signaling differences between the tumor core and periphery involve distinct gene expression patterns and signaling pathways. In the tumor periphery, there is enhanced proliferation driven by factors like FGF-2 through the PI3K/AKT pathway, leading to downregulation of the CDK inhibitor p27Kip1. On the other hand, the tumor core exhibits unique transcriptional and signaling profiles related to wound healing and GP6 signaling pathways, as well as intrinsic prothrombin activation and MSP-RON signaling pathways. Additionally, the tumor core and periphery show differential gene expression, with the periphery having higher intercellular signaling, including pathways linked to invasion and metastasis like collagen and non-canonical WNT pathways. These findings highlight the intricate molecular landscape that contributes to the heterogeneity within tumors.
What is the viscocity and elasticity numerical value of benign and malignant human lung surface stiffness?5 answersThe stiffness and viscoelasticity of benign and malignant human lung surface stiffness have been studied. The stiffness of lung cancer cell lines was found to be significantly lower than that of normal bronchial epithelial cells, indicating that soft cell stiffness is a potential indicator of lung cancer diagnosis. Additionally, a technique involving surface wave propagation and ultrasound imaging was proposed as a noninvasive method to measure the local lung tissue mechanical properties, showing potential for quantifying lung regional stiffness. Furthermore, a study characterized the stiffness and viscoelasticity of nondiseased and diseased lung tissue, demonstrating the possibility to generate extracellular matrix (ECM) hydrogels with similar stiffness to native tissue. Finally, a study using PET imaging showed that the uptake of [11C]4DST in lung tumors correlated with the proliferative activity of tumors, suggesting a noninvasive imaging method for assessing DNA synthesis in malignant lung tumors.
What are the differences in the mechanical properties of cancer and healthy cells?5 answersThe mechanical properties of cancer cells differ from those of healthy cells. Cancer cells exhibit abnormally high solid stress, spatially heterogeneous changes in intrinsic mechanical tissue properties, and changes in viscoelasticity, force generation, and mechanosensing. These changes in mechanical properties enable cancer cells to migrate, invade surrounding tissues, and contribute to tumor progression and metastasis. Biomechanical properties of cancer cells and their surrounding extracellular matrix have been proposed as promising biomarkers for cancer diagnosis and prognosis. The cytoskeleton plays a crucial role in the biomechanics of cancer cells, affecting cell morphology and interaction with the microenvironment. The mechanical properties of cancer cells are influenced by their shape, size, and other physical parameters, with a maximum migratory index occurring at a specific range of cell bulk elasticity. The investigation of adhesion G protein-coupled receptors (aGPCRs) and their mechanosensitive function may provide insights into the mechanobiology of cancer cells.
Does breast cancer pain move around?10 answers