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What is the impact of neurotoxins in sensory neurons in zebrafish? 

PINK1
MPTP
Neuropathy target esterase
Neurotoxin
Dopaminergic Cell
Best insight from top research papers

Neurotoxins have been shown to have an impact on sensory neurons in zebrafish. Bisphenol F (BPF) exposure led to inhibited locomotion, reduced moving distance, and central nervous system (CNS) cell apoptosis, indicating neurotoxicity . MPTP, MPP+, and rotenone exposure caused dopaminergic (DAnergic) cell loss in the ventral diencephalon (vDC) region, resulting in motor deficits . Diisopropylfluorophosphate (DFP) exposure caused CNS neuron hyperactivation, increased neuronal apoptosis, and altered glutamatergic/GABAergic synaptic activity . However, zebrafish did not show neurological abnormalities or changes in phosphatidylcholines (PCs), lysophosphatidylcholines (LPCs), and glycerolphosphocholine (GPC) profiles after exposure to neuropathic organophosphorus compounds (OPs) . Additionally, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exposure induced mitochondrial fragmentation in dopaminergic neurons and activated the pink1/parkin pathway involved in mitophagy .

Answers from top 5 papers

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Papers (5)Insight
Open access•Journal Article•DOI
Organophosphorus diisopropylfluorophosphate (DFP) intoxication in zebrafish larvae causes behavioral defects, neuronal hyperexcitation and neuronal death.
Alexandre Brenet, Julie Somkhit, Rahma Hassan-Abdi, Constantin Yanicostas, Christiane Romain, Olivier Bar, Alexandre Igert, Dominique Saurat, Nicolas Taudon, Gregory Dal-Bo, Florian Nachon, Nina Dupuis, Nadia Soussi-Yanicostas 
05 Nov 2020-Scientific Reports
11 Citations
The provided paper does not specifically mention the impact of neurotoxins on sensory neurons in zebrafish.
Open access•Journal Article•DOI
Cerebroventricular Microinjections of MPTP on Adult Zebrafish Induces Dopaminergic Neuronal Death, Mitochondrial Fragmentation, and Sensorimotor Impairments.
Michael Kalyn, Marc Ekker 
27 Aug 2021-Frontiers in Neuroscience
7 Citations
The paper does not specifically mention the impact of neurotoxins on sensory neurons in zebrafish. The paper focuses on the impact of the neurotoxin MPTP on dopaminergic neurons, mitochondrial fragmentation, and sensorimotor impairments in adult zebrafish.
Journal Article•DOI
Bisphenol F-Induced Neurotoxicity toward Zebrafish Embryos
Lilai Yuan, Le Qian, Yu Qian, Jia Liu, Ke Yang, Ying Huang, Chengju Wang, Yingren Li, Xiyan Mu 
08 Nov 2019-Environmental Science & Technology
62 Citations
The provided paper does not specifically mention the impact of neurotoxins on sensory neurons in zebrafish.
Open access•Journal Article•DOI
Analysis of the neurotoxic effects of neuropathic organophosphorus compounds in adult zebrafish.
Melissa Faria, Inmaculada Fuertes, Eva Prats, José Luis Abad, Francesc Padrós, Cristian Gómez-Canela, Josefina Casas, Jorge Estévez, Eugenio Vilanova, Benjamin Piña, Demetrio Raldúa 
19 Mar 2018-Scientific Reports
9 Citations
The provided paper does not mention the impact of neurotoxins on sensory neurons in zebrafish.
Open access•Journal Article•DOI
Comprehensive Analysis of Neurotoxin-Induced Ablation of Dopaminergic Neurons in Zebrafish Larvae.
Michael Kalyn, Khang Hua, Suzita Mohd Noor, Chee Ern David Wong, Marc Ekker 
28 Dec 2019-Biomedicines
37 Citations
The provided paper does not mention the impact of neurotoxins on sensory neurons in zebrafish.

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