What is the latest research about N-iodosuccinimide?
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N-iodosuccinimide (NIS) has been the focus of recent research. Ajvazi and Stavber reported an efficient and selective methodology for the direct cross-coupling of alcohols with N-nucleophiles using NIS as the precatalyst, enhancing the green chemical profiles of these reactions . Chen et al. demonstrated an NIS-promoted cyclization of alkylidene oxindoles with annular β-dicarbonyl compounds, providing a practical synthesis of structurally diverse spirooxindoles . Ajvazi and Stavber also reported the use of NIS for the direct cross-coupling of benzyl alcohols with C-nucleophiles under solvent-free reaction conditions, providing large-scale synthesis with almost quantitative yields . Apih et al. investigated halogen bonded complexes of NIS using nuclear quadrupole resonance spectroscopy, revealing the deformation of nitrogen electron orbitals caused by the halogen bond . Ai Ti Re He Man et al. developed a method for the synthesis of N2-allyl-substituted 1,2,3-triazoles using NIS, which selectively gave the desired N2-allylation products .
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01 Jul 2019 2 Citations | The provided paper is about the study of donor-acceptor interaction in halogen bonded complexes of N-iodosuccinimide. It does not provide information about the latest research on N-iodosuccinimide. |
| The latest research about N-iodosuccinimide (NIS) is its use as a non-metal, accessible, and environmentally friendly precatalyst for direct cross-coupling of alcohols with N-nucleophiles under mild reaction conditions. | |
| The provided paper is about the N-iodosuccinimide-promoted selective construction of cyclopropyl and dihydrofuranyl spirooxindoles from alkylidene oxindoles and annular β-dicarbonyl compounds. It does not provide information about the latest research on N-iodosuccinimide. | |
| The latest research about N-iodosuccinimide is its use as a precatalyst for direct cross-coupling of benzyl alcohols with C-nucleophiles under solvent-free reaction conditions, providing large-scale synthesis with almost quantitative yields. |
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