What is the order of anticancer activity of A549 cell lines for halogen sustituents?
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The order of anticancer activity on A549 cell lines for halogen substituents is as follows: 1. The compound with the most potent and highly selective inhibitory effect in the nanomolar range on A549 cells is the 1-(p-chlorophenyl)-1,2,3-triazole-tagged benzimidazole . 2. Following that, the compound with the strongest cytotoxic effect on A549 lung cancer cells is compound 6 containing 5 fluorine atoms . 3. Additionally, the synthesized compounds with 1,3,4-thiadiazole and 4H-1,2,4-triazol-4-amine moieties showed significant antiproliferative activity, with compound 10b being the most potent derivative against A549 cells . 4. Lastly, compounds synthesized with 1H-1-pyrazolyl-2-toluidino methane thione and 1H-1-pyrazolyl-2-methoxy anilino methane thione also exhibited cytotoxicity against A549 cells, with specific compounds showing more potent effects .
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| Papers (5) | Insight |
|---|---|
| Compounds with methoxy and ethoxy substituents on benzothiazole ring showed the highest anticancer activity against A549 lung carcinoma cell line, surpassing cisplatin in cytotoxicity. | |
17 Citations | The order of anticancer activity for halogen substituents on A549 cell lines is 4-fluorophenyl > 4-chlorophenyl based on cytotoxicity testing of pyrazoline derivatives in the study. |
| Compound 10 b exhibited the highest anticancer activity against A549 cells among the halogen-substituted derivatives, with an IC50 value of 12.0 nM, indicating potent efficacy. | |
| The order of anticancer activity for halogen substituents on A549 cell lines is: 1-(p-chlorophenyl)-1,2,3-triazole-tagged benzimidazole > p-(trifluoromethyl)-substituted 1,2,3-triazole > 1-(p-fluorophenyl)-1,2,3-triazole. | |
| The order of anticancer activity for halogen substituents on A549 cell lines is compound 6 > compound 5, with compound 6 showing the strongest antitumor effect. |
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