M
Mirela Sedić
Researcher at University of Rijeka
Publications - 56
Citations - 1197
Mirela Sedić is an academic researcher from University of Rijeka. The author has contributed to research in topics: Cancer & HeLa. The author has an hindex of 14, co-authored 55 publications receiving 997 citations. Previous affiliations of Mirela Sedić include University of Zagreb.
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Journal ArticleDOI
Novel Cyano- and Amidino-Substituted Derivatives of Styryl-2-Benzimidazoles and Benzimidazo[1,2-a]quinolines. Synthesis, Photochemical Synthesis, DNA Binding, and Antitumor Evaluation, Part 3
Marijana Hranjec,Marijeta Kralj,Ivo Piantanida,Mirela Sedić,Lidija Šuman,Krešimir Pavelić,Grace Karminski-Zamola +6 more
TL;DR: The most active imidazolyl-substituted compound 19 inhibits topoisomerase II and induces strong G2/M cell cycle arrest, pointing to the impairment in mitotic progression.
Journal ArticleDOI
Metastasis: new perspectives on an old problem.
TL;DR: A current overview of molecular mechanisms underpinning metastasis is provided, and recent findings in this field obtained by global molecular profiling strategies such as proteomics are discussed.
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Synthesis, in vitro anticancer and antibacterial activities and in silico studies of new 4-substituted 1,2,3-triazole-coumarin hybrids.
Tatjana Gazivoda Kraljević,Anja Harej,Mirela Sedić,Sandra Kraljević Pavelić,Višnja Stepanić,Domagoj Drenjančević,Jasminka Talapko,Silvana Raić-Malić +7 more
TL;DR: It is indicated that coumarin-1,2,3-triazole could be used as the scaffold for structural optimization to develop more potent and selective anticancer agents and encourage further development of novel structurally related analogs of 33 as more effective 5-LO inhibitors.
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Novel 1,2,4-triazole and imidazole derivatives of l-ascorbic and imino-ascorbic acid: Synthesis, anti-HCV and antitumor activity evaluations
Karlo Wittine,Maja Stipković Babić,Damjan Makuc,Janez Plavec,Sandra Kraljević Pavelić,Mirela Sedić,Krešimir Pavelić,Pieter Leyssen,Johan Neyts,Jan Balzarini,Mladen Mintas +10 more
TL;DR: Results of this study put forward compound 6 as a potential novel antitumor agent (IMPDH inhibitor) for treating leukaemia because of its significant biological activity and low toxicity in human diploid fibroblasts, encourage further development of this compound as a lead.
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Design, synthesis and biological evaluation of novel benzimidazole amidines as potent multi-target inhibitors for the treatment of non-small cell lung cancer.
Andrea Bistrović,Luka Krstulović,Anja Harej,Petra Grbčić,Mirela Sedić,Sanja Koštrun,Sandra Kraljević Pavelić,Miroslav Bajić,Silvana Raić-Malić +8 more
TL;DR: Western blot analyses showed different mechanisms of cytostatic activity between compounds 10c and 11f that could be associated with the nature of aromatic substituent at 1-(1,2,3-triazolyl) and amidino moiety at C-5 position of benzimidazole ring.