What is the physiological role of ATP citrate synthase?
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ATP citrate synthase plays a key role in energy production in the mitochondria by utilizing acetyl-CoA and oxaloacetate to form citrate . It is involved in the tricarboxylic acid (TCA) cycle and the electron transport chain, contributing to the synthesis of acetylcholine (ACh) in neuronal cytoplasm . In a mature brain, acetyl-CoA produced by ATP citrate synthase is mainly utilized for ACh synthesis, which is responsible for memory and cognition . Studies have shown that reduced ATP citrate synthase activity in Alzheimer's disease (AD) patients leads to decreased cellular bioenergetics, acetyl-CoA, and ACh synthesis, which contributes to the pathophysiology of AD . Therefore, ATP citrate synthase is crucial for cellular energy production and neurotransmitter synthesis, making it a potential therapeutic target for AD .
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