What is the relationship between aldehyde dehydrogenase and psychiatric factors?
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Aldehyde dehydrogenase (ALDH) is involved in the metabolism of aldehydes and has been implicated in various psychiatric factors. Studies suggest that ALDH dysfunction may play a role in neurodegenerative disorders such as Parkinson's disease (PD) and Alzheimer's disease (AD) . ALDH2, a subtype of ALDH, is particularly important in the central nervous system (CNS) as it eliminates metabolites of neurotransmitters and endogenous aldehydes . ALDH2 polymorphism has been associated with the risk of several diseases, including neurodegenerative diseases, and its activation has shown protective effects in animal models . Additionally, aldehyde derivatives of catecholamines and indoleamines, which are metabolized by ALDH, have been implicated in the brain and may contribute to psychiatric factors . Further research is needed to fully understand the relationship between ALDH and psychiatric factors, but targeting ALDH2 has shown potential as a therapeutic strategy .
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