What is the relationship between cholesterol and glucose?
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Cholesterol and glucose are closely related in human physiological activities. Glucose metabolism has been found to regulate cholesterol synthesis, and glucose breakdown provides the energy needed for cholesterol production . On the other hand, cholesterol can affect glucose utilization efficiency, leading to endoplasmic reticulum stress and inflammation . Glucose and insulin stimulate cholesterol biosynthesis and uptake, which are targeted by lipid-lowering drugs . In Alzheimer's disease, both cholesterol and glucose dysmetabolism contribute to disease progression, with oxidized cholesterol and altered glucose uptake playing key roles . Additionally, cholesterol can influence blood glucose measurements, and a method using near-infrared spectroscopy has been proposed to reduce the prediction errors induced by cholesterol . Overall, the relationship between cholesterol and glucose is complex and involves various mechanisms and pathways.
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| Papers (5) | Insight |
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| The paper discusses the bidirectional crosstalk between brain cholesterol and glucose metabolism in Alzheimer's disease, suggesting that cholesterol dysmetabolism and altered glucose uptake are both involved in the disease's progression. However, the specific relationship between cholesterol and glucose is not clearly defined in the paper. | |
| The paper discusses the relationship between glucose and cholesterol metabolism, stating that glucose/insulin promotes cholesterol biosynthesis and uptake. | |
| The paper states that there is a strong negative correlation between the changes of glucose and cholesterol concentrations in the diabetes group. | |
| The paper discusses the links between cholesterol synthesis and glucose metabolism, suggesting that glucose catabolism regulates cholesterol synthesis. However, the precise mechanism is not fully understood. | |
| The paper states that cholesterol can attenuate glucose utilization efficiency in pancreatic cells and mice, suggesting that there is a negative relationship between cholesterol and glucose utilization. |
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