scispace - formally typeset
Search or ask a question

What is the relationship between crescimento and diminuioção of indice mitotico caudado por nanoparticulas polimericas? 


Best insight from top research papers

The relationship between the growth and decrease of the mitotic index caused by polymeric nanoparticles can vary based on the concentration and type of nanoparticles used. Studies have shown that higher concentrations of gold nanoparticles lead to a decrease in the mitotic index, indicating cytotoxic effects and genotoxicity . On the other hand, exposure to copper oxide nanoparticles has been linked to significant decreases in the mitotic index in plant cells, especially at higher concentrations, causing abnormalities in cell division . These findings highlight the potential impact of nanoparticles on mitotic activity, suggesting that different types of nanoparticles can have varying effects on mitotic indices, potentially influencing cell growth and division processes.

Answers from top 5 papers

More filters
Papers (5)Insight
The enhanced internalization of nanoparticles following ionizing radiation led to mitotic catastrophe in MG-63 human osteosarcoma cells, indicating increased mitotic index due to nanoparticle exposure.
Not addressed in the paper.
Not addressed in the paper.
Not addressed in the paper.
Not addressed in the paper.

Related Questions

How does cancer impact the process of mitosis in human cells?5 answersCancer significantly impacts the process of mitosis in human cells by inducing DNA damage and affecting cell division. Mitotic checkpoints can be delayed or disrupted in cancer cells, leading to defects in chromosome-spindle interactions and DNA breaks during mitotic arrest. Additionally, tumors exhibit lower mitotic indices and reduced proapoptotic responses compared to cell culture when exposed to antimitotic drugs like paclitaxel, resulting in multinucleation and delayed cell death. Furthermore, in the presence of mutations in DNA repair genes like BRCA1 or BRCA2, DNA lesions induced by PARP inhibitors are transferred into mitosis, giving rise to sister chromatid exchanges and deletions, contributing to genomic instability in cancer cells. These findings highlight the intricate relationship between cancer and mitosis, emphasizing the importance of understanding these processes for developing effective cancer therapies.
Why mitotic cells are more sensitive to radiation therapy?5 answersMitotic cells exhibit heightened sensitivity to radiation therapy due to various mechanisms. Studies suggest that radiation induces mitotic chromosome segregation errors, leading to long-lasting aneuploidy and micronuclei formation, amplifying genome damage in cancer cells. Additionally, cancer cells resist irradiation by inducing regulated DNA breaks to prevent premature mitotic entry. Furthermore, microtubule-targeting agents like mebendazole sensitize interphase cancer cells to radiation by interfering with DNA damage response protein trafficking, independent of mitotic arrest induction. Targeting SP1, involved in tumor maintenance, with mithramycin A enhances radiation sensitivity in tumor cells by promoting mitotic catastrophe and suppressing cell death-related gene transcription. These combined factors contribute to the increased vulnerability of mitotic cells to radiation therapy.
What is the mitotic index of onion root tips?5 answersThe mitotic index of onion root tips varied across the different studies. In one study, the mitotic index ranged from 8.4% to 5.7% when treated with different concentrations of lead acetate. Another study found that treatment with different concentrations of NaCl resulted in a mitotic index decrease from 12% to 9.11%. The cytotoxic effects of the crude aqueous extract of Raphanus sativus led to a reduction in the mitotic index to less than 50%, with values of 23.72% and 41.89% observed at different concentrations. The cytoxicity of green synthesis silver nanoparticles also affected the mitotic index, with a decrease observed as the concentration of AgNPs increased, except at 5mg/L where the mitotic index was higher than the control. Finally, the methanol, water, and hexane extracts of Annona muricata showed significant drops in the mean mitotic index at different concentrations.
What are the recent discoveries in nanopsicology?3 answersNanotoxicology is a multidisciplinary field that studies the adverse effects of manufactured nanomaterials in biological systems. Recent progress has been made in this field, but some key questions still remain unanswered. Nanomineralogy has also made significant advancements, allowing for the characterization of earth and planetary materials at the nano-scale. New minerals with geological significance and nano-features in common minerals and gems have been discovered. Nanoparticle research is a rapidly developing field that offers countless opportunities for surprising discoveries. Scientists are working on developing synthesis approaches, characterization tools, and models to explain the behavior of nanoparticles. The research in this field covers various aspects, including historical aspects, basic and applied science, and commercial applications. The field of nanosafety has seen exponential growth in the number of studies published on nanotoxicology. However, many of these studies lack clear statements on the safety of nanomaterials and have deficiencies in their design and methods. Future improvements are needed in the design and execution of nanotoxicological studies. Nanotoxicology has made significant progress in recent years, with advancements in synthesis techniques, characterization technologies, and the correlation of physical parameters to physiological responses. However, the field still faces challenges such as establishing full characterization requirements, standardization of dosimetry, and improving in vitro to in vivo predictive efficiencies.
How mitosis is significant for organism?5 answersMitosis is significant for organisms because it is essential for the development and reproduction of cells. It ensures that each new cell is genetically identical to the parent cell. Mitosis is crucial for normal growth, development, and tissue repair. It is tightly regulated to ensure accurate segregation of chromosomes into each new daughter cell, preventing genetic imbalances and diseases like cancer. Additionally, mitosis may have additional functions essential for differentiation and tissue reorganization. The process of mitosis involves deep structural and molecular changes that can impact cell and tissue fate and shape. Understanding the molecular mechanisms and regulation of mitosis provides insights into disease pathology and tissue development.
What is mitosis in software testing?7 answers