What is the role of lactate in neurotransmission?
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Lactate plays a role in neurotransmission by modulating synaptic transmission and neuronal excitability. It has been shown to attenuate neurotransmitter release from presynaptic terminals in both excitatory pyramidal cells and inhibitory interneurons . Lactate also affects synaptic plasticity-related intracellular signaling cascades, including the activation of NMDA receptors and postsynaptic calcium accumulation . Additionally, lactate can act as a volume transmitter, linking neuronal activity, cerebral energy metabolism, and energy substrate availability . The G-protein-coupled lactate receptor, GPR81, is present in the brain and can be activated by lactate to reduce cAMP levels . This suggests that lactate may have a role in regulating neurotransmission and synaptic potentiation at central synapses . Overall, lactate's involvement in neurotransmission highlights its potential impact on neuronal function and brain energy metabolism.
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18 Citations | Lactate modulates synaptic plasticity and memory formation by enhancing synaptic strength through a postsynaptic receptor. |
| The paper states that lactate supports synaptic transmission, neuronal plasticity, and memory consolidation, even in the presence of ample glucose. | |
22 Citations | Lactate attenuates synaptic transmission by reducing neurotransmitter release from presynaptic terminals, but does not affect action potential generation in the axon. |
| The paper states that lactate attenuates neurotransmission in glutamatergic pyramidal cells and GABAergic interneurons by reducing neurotransmitter release from presynaptic terminals. |
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