What is the summary of Reactions of carboxylic acids?
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Reactions of carboxylic acids involve nucleophilic addition to the carbonyl group, followed by elimination of the leaving group. Acid-catalyzed protonation or complexation with a Lewis acid increases the electrophilic character of the carbonyl group. Esters and amides can also act as electrophiles, but when they have at least one hydrogen atom, they can generate nucleophiles through reaction with bases. Carboxylic acids can act as both C- and O-nucleophiles, and they can also be employed as electrophiles in asymmetric reactions under catalytic conditions. Carboxylic acids are stable surrogates for organohalides or organometallic reagents in transition metal-catalyzed cross-coupling reactions. They can undergo decarboxylation to form carbon-centered radicals, enabling novel C(sp3)-C bond disconnections. These reactions have significant implications for organic synthesis.
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| The paper discusses the reaction of carboxylic acids in an electric field, where they undergo decarboxylation to form radicals that can dimerize to produce a product. The reaction may occur away from the electrodes or at the electrode surfaces. | |
| The paper discusses the addition-elimination reactions of carboxylic acids and their derivatives, including esterification, hydrolysis, and generation of alcohols and ketones. | |
8 Citations | The paper discusses the use of carboxylic acids as building blocks in catalytic asymmetric reactions, but it does not provide a specific summary of the reactions of carboxylic acids. |
| The paper discusses the general reactivity patterns of carboxylic acids and their derivatives, including nucleophilic addition to the carbonyl group, elimination reactions, enolate formation, and acid-base reactions. |
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