What is Thiacetamide?
Best insight from top research papers
Thioacetamide (TAA) is an organosulfur compound that is used in various industries such as leather processing, laboratories, textile, and paper industries . It is known to be a model hepatotoxicant and is used to induce acute and chronic liver injury in experimental studies . TAA undergoes a two-step bioactivation process in the liver, leading to the formation of reactive metabolites that can cause cellular necrosis and liver damage . Prolonged exposure to TAA has been associated with the development of liver nodules, adenomas, cholangiomas, and hepatocarcinomas . Additionally, TAA has been used as a model for studying hepatic encephalopathy, with studies investigating its effects on electroencephalographic (EEG) changes in rats . Overall, TAA is a widely studied compound that is used to understand the mechanisms of liver injury and hepatic encephalopathy in experimental models .
Answers from top 4 papers
More filters
| Papers (4) | Insight |
|---|---|
7 Citations | Thioacetamide (TAA) is a compound used as a model of hepatic encephalopathy (HE) in rats, as mentioned in the provided paper. |
| Thioacetamide (TA) is a hepatotoxicant that undergoes bioactivation mediated by cytochrome P450 (CYP)2E1 to form reactive metabolites that cause cellular necrosis. | |
42 Citations | Thioacetamide (TAA) is an organosulfur compound that is used as a model hepatotoxicant to induce acute and chronic liver injury. |
72 Citations | Thiacetamide is not mentioned in the provided paper. The paper is about the identification and characterization of a thioviridamide-like compound with selective anticancer activity. |
Related Questions
What is th?4 answersThyroid hormone (TH) is a multifaceted entity with diverse implications. It serves as a pivotal modulator in biological processes across species, playing a crucial role in development, metabolism, and response to environmental stimuli. TH influences cellular energy metabolism, triggering reactive oxygen species generation and redox signaling, which in turn protect cells through various mechanisms. Additionally, TH can be viewed as a test harness facilitating the development of scientific software by comparing results from different versions of an application code to ensure equivalence, with the flexibility to be activated or deactivated as needed. Furthermore, TH has been historically linked to philosophical ideologies, symbolizing a transformative force akin to a radical revolution through technological advancements.
What is nicotinamide used for?5 answersNicotinamide, also known as niacinamide, is utilized for various purposes based on research findings. It serves as a precursor to nicotinamide adenine dinucleotide (NAD+), playing a crucial role in cellular metabolism, DNA repair, and defense against oxidative stress. Nicotinamide demonstrates diverse biological functions, including anti-inflammatory, antibacterial effects, and modulation of cellular immunity, making it beneficial for skin and neurodegenerative diseases. Additionally, nicotinamide is explored for its vasoprotective, anti-atherosclerotic, and cardioprotective properties, suggesting its potential in improving blood microcirculation and combating obesity. In the context of glaucoma, nicotinamide and its derivative nicotinamide riboside are emerging as adjuvant therapies to prevent optic nerve damage by replenishing NAD levels and enhancing cellular functioning. These findings collectively highlight the broad spectrum of applications for nicotinamide in medicine and health maintenance.
What is the dose of thioacetamide rats treated with pirfenidone for 4 weeks liver fibrosis?4 answersThe dose of thioacetamide (TAA) used in rats treated with Pirfenidone for liver fibrosis was not specified for a 4-week duration in the provided contexts. However, the contexts provide valuable insights into the effects of Pirfenidone on liver injury in different rat models of liver fibrosis. Rong Xie et al. demonstrated the effects of Pirfenidone on high-fat diet (HFD)-fed mice, showing significant improvements in liver pathology, inflammation, and oxidative stress. Additionally, Nathaly Enciso et al. established a model of advanced hepatic fibrosis in rats using TAA, paving the way for potential therapies like mesenchymal stem cells for fibrosis regression. While the exact dose for a 4-week treatment is not explicitly mentioned, these studies collectively highlight the potential of Pirfenidone in ameliorating liver fibrosis in different experimental settings.
What is Thiocoraline?5 answersThiocoraline is a potent antitumor agent that is isolated from marine actinomycete Micromonospora marina. It is a nonribosomally biosynthesized bisintercalator natural product, containing S-methylated l-cysteine residues in its peptidic backbone. Thiocoraline has shown promising results in inhibiting the growth of neuroendocrine tumors (NETs) such as carcinoids and medullary thyroid cancer (MTC). It activates the Notch pathway, leading to tumor suppression and a decrease in cell proliferation. Thiocoraline has also been studied for its binding properties to DNA, showing a long-lived bis-intercalated complex with slow off-rate and sequence selectivity. Overall, thiocoraline has demonstrated potential as a therapeutic agent for the treatment of various types of cancer, particularly NETs, by targeting specific signaling pathways and inhibiting tumor growth.
Do Thiourea effects thyroid?5 answersThiourea has effects on the thyroid. It was found to be a thyroid carcinogen at certain dietary levels in rats. In another study, rats treated with ethylenethiourea (ETU) showed changes in thyroid function, including reduced capacity to bind T3. Additionally, thiourea was found to significantly decrease thyroidal 131I accumulation in Xantusia henshawi lizards. Thiourea also has goitrogenic effects, inhibiting growth and causing an increase in granulation in pituitary somatotrophs. These findings suggest that thiourea can have various effects on the thyroid, including carcinogenic and goitrogenic effects, as well as alterations in thyroid function.
What is thiamine?5 answersThiamine, also known as vitamin B1, is a water-soluble vitamin that is essential for energy metabolism and the tricarboxylic acid cycle. It is not produced by the body, so it must be obtained through the diet. Thiamine is found in foods such as tarwekiemen, graanproducten, rijst, vlees, noten, groenten, and gist. Thiamine plays a crucial role in critical enzyme complexes involved in intermediary metabolism, including pyruvate decarboxylase, α-ketoglutarate dehydrogenase, and branched-chain α-ketoacid dehydrogenase. Thiamine deficiency can lead to conditions such as Wernicke's encephalopathy or Wernicke-Korsakoff syndrome in adults with chronic alcoholism, as well as in children with neoplasms, anorexia nervosa, hemodialysis, and certain inherited metabolic disorders. Thiamine is also used as a drug for anesthesia, analgesia, and intensive care. Overall, thiamine is an important nutrient that is necessary for proper bodily function and energy production.