Anna Rita Cappello

TL;DR: It is shown that new mitochondrial biogenesis is required for the anchorage independent survival and propagation of cancer stem-like cells (CSCs) and that doxycycline could be re-purposed clinically as a ‘safe’ mitochondrial inhibitor, to target FOXM1 and mitochondrialBiogenesis in CSCs, to prevent tumor recurrence and distant metastasis, thereby avoiding patient relapse.

TL;DR: Graphene oxide is shown to be an effective non-toxic therapeutic strategy for the eradication of cancer stem cells, via differentiation-based nano-therapy and Mechanistically, it is presented evidence that GO exerts its striking effects on CSCs by inhibiting several key signal transduction pathways and thereby inducing CSC differentiation.

TL;DR: It is shown for the first time that atovaquone also has anti-cancer activity, directed against Cancer Stem-like Cells (CSCs), and results indicate that glycolysis itself is not sufficient to maintain the proliferation of CSCs, which is instead strictly dependent on mitochondrial function.

TL;DR: The analgesic property of quercetin, intrinsically linked to its anti-inflammatory action, has been evaluated, to investigate about an innovative approach to this interesting natural compound, such as analgesic remedial.

TL;DR: It is shown that copper sulfate (CuSO4) induces the expression of HIF-1α as well as GPER and VEGF in breast and hepatic cancer cells through the activation of the EGFR/ERK/c-fos transduction pathway.