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What is zebrafish model used in vivo study?

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The zebrafish model is extensively utilized for in vivo studies across various research areas. Zebrafish embryos offer advantages like transparency, ease of handling, and the absence of adaptive immunity, making them ideal for xenograft development and drug delivery system evaluation . Zebrafish are also employed for ocular disease gene screening, with established assays for ocular biometry, refractive status, intraocular pressure, and visual function assessment . Furthermore, zebrafish larvae have a fully functional pronephron, resembling higher vertebrates, making them valuable for drug disposition studies and bridging the gap between cell culture models and pharmacokinetic experiments . In the realm of neurological disorders like autism spectrum disorder (ASD), zebrafish serve as a promising model due to genetic similarities, brain anatomy parallels, and neurotransmitter system resemblances with humans, aiding in drug discovery efforts . Additionally, the zebrafish embryo tuberculosis model is utilized for evaluating the toxicity and efficacy of anti-TB compounds, providing a quick and sensitive tool for early-stage drug development .

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Open access•Journal Article•DOI The zebrafish embryo as an <i>in vivo</i> model for screening nanoparticle-formulated lipophilic anti-tuberculosis compounds 01 Jan 2022-Disease Models & Mechanisms 5 Citations	The zebrafish embryo model is utilized for in vivo screening of nanoparticle-formulated lipophilic anti-tuberculosis compounds, assessing toxicity, efficacy, and potential for drug development.
Open access•Journal Article•DOI Zebrafish Modeling of Autism Spectrum Disorders, Current Status and Future Prospective Akram Tayanloo-Beik, Shayesteh Kokabi Hamidpour, Mina Abedi, Hamide Shojaei, Mostafa Rezaei-Tavirani, Nazli Namazi, Bagher Larijani, Babak Arjmand - Show less +7 more 14 Jul 2022-Frontiers in Psychiatry 5 Citations	Zebrafish model is utilized in vivo for preclinical studies on Autism Spectrum Disorders due to genetic and non-genetic modeling methods, anatomical similarities, and shared neurotransmitter systems with humans.
Open access•Journal Article•DOI Zebrafish (Danio rerio) larva as an in vivo vertebrate model to study renal function Jan Stephan Bolten, Anna Pratsinis, Claudio L. Alter, Gert Fricker, Jörg Huwyler - Show less +4 more 17 Jan 2022 9 Citations	Zebrafish larvae serve as an in vivo vertebrate model to study renal function, showcasing a fully functional pronephron at 3-4 days post-fertilization, aiding drug disposition research.
Open access•Journal Article•DOI Zebrafish: A Useful Animal Model for the Characterization of Drug-Loaded Polymeric NPs Sara Bozzer, Luca De Maso, Maria Cristina Grimaldi, Sara Capolla, Michele Dal Bo, Giuseppe Toffoli, Paolo Macor - Show less +6 more 01 Sep 2022-Advances in Cardiovascular Diseases 2 Citations	Zebrafish (ZF) embryos serve as an in vivo model due to their transparency, ease of handling, and lack of adaptive immunity initially. They are utilized to study drug-loaded polymeric NPs for B-cell malignancies.
Open access•Journal Article•DOI Zebrafish: An In Vivo Screening Model to Study Ocular Phenotypes Wim Hendricus Quint, Kirke C. D. Tadema, Johan H C Crins, Nina C. C. J. Kokke, Magda A. Meester-Smoor, Rob Willemsen, Caroline C W Klaver, Adriana I Iglesias - Show less +7 more 01 Mar 2022-Translational Vision Science & Technology 2 Citations	Zebrafish model is utilized for in vivo screening of ocular phenotypes, including ocular biometry, refractive status, intraocular pressure, and visual function, showcasing its potential for genetic screenings of candidate genes.

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