What kind of reaction occur in the bromination test for aniline?
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The bromination test for aniline involves the electrophilic bromination reaction, which typically leads to ortho- and para-bromination due to the electron-rich nature of anilines . This reaction can be challenging due to the competing ortho/para selectivity. However, the use of N-bromophthalimide (NBP) as a brominating agent in the presence of acid additives enables the unprecedented Pd-catalyzed meta-C–H bromination of aniline derivatives, overcoming the selectivity issues associated with traditional electrophilic bromination . Additionally, the regioselectivity of the bromination reaction can be influenced by the polarity of the solvent and the choice of reaction medium when anilines are substituted with electron-withdrawing groups in the meta position . This method offers a practical approach for the synthesis of bromoanilines with high yields and regioselectivity .
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2 Citations | The bromination of anilines involves a regioselective reaction catalyzed by copper, utilizing NaBr and Na2S2O8 to introduce bromine selectively onto the aniline molecule. |
9 Citations | Electrophilic aromatic bromination takes place in the bromination test for meta-substituted anilines using N-bromosuccinimide, with regioselectivity influenced by solvent polarity. |
15 Citations | Electrophilic bromination of anilines with various substituents in the aromatic ring leads to the synthesis of mono-, di-, tri-, and tetrabromo derivatives, including a brominated analog of Aniline Black. |
| In the bromination test for aniline, a Pd-catalyzed meta-C–H bromination reaction occurs, overcoming ortho- and para-selectivity issues typically associated with electrophilic bromination of anilines. | |
2 Citations | In the bromination test for anisole, a bromination reaction occurs, triggered by N-Bromophthalimide in the presence of aqueous acetic acid, leading to the formation of bromo derivatives of anisole. |
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