What microRNAs are deregulated in melanoma?
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In melanoma, various microRNAs (miRNAs) are deregulated, serving as potential biomarkers for disease progression and metastasis. Some of the deregulated miRNAs include miR-200c, miR-205, miR-23b, miR-146a, and miR-155, which show consistent dysregulation in melanocytes, melanoma cell lines, and patient samples. Additionally, miR-145-5p, miR-106a-5p, miR-17-5p, miR-20b-5p, miR-200b-3p, miR-200a-3p, miR-20a-5p, and miR-19b-3p are identified as deregulated miRNAs in vaginal and vulvar melanomas. Furthermore, miR-363-3p, miR-196b-5p, miR-135b-5p, miR-223-3p, and miR-376c-5p are found to be significantly upregulated or downregulated in ulcerated melanomas, highlighting their role in disease pathology. These deregulated miRNAs offer insights into the molecular mechanisms underlying melanoma progression and provide potential targets for diagnostic and therapeutic interventions.
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| Papers (5) | Insight |
|---|---|
| Deregulated microRNAs in melanoma include hsa-miR-149-3p, hsa-miR-150-5p, hsa-miR-193a-3p, hsa-miR-21-5p, and hsa-miR-155-5p, with hsa-miR-150-5p and hsa-miR-155-5p showing diagnostic potential in advanced melanoma. | |
| Redox-sensitive microRNAs are deregulated in melanoma, influenced by UV radiation, contributing to melanomagenesis and potential therapeutic targets for prevention and treatment. | |
| In ulcerated melanoma, miR-363-3p, miR-196b-5p, miR-135b-5p, and miR-223-3p are upregulated, while miR-376c-5p is downregulated, impacting angiogenesis and metastasis. | |
| In melanoma, miR-145-5p, miR-106a-5p, miR-17-5p, miR-20b-5p are deregulated in vaginal melanoma, while miR-200b-3p, miR-200a-3p, miR-20a-5p, miR-19b-3p are deregulated in vulvar melanoma. | |
30 Mar 2023 | MicroRNAs-200c, 205, and 23b are downregulated, while miR-146a and miR-155 are upregulated in melanoma, suggesting their potential as biomarkers for the disease. |
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