What role do microRNAs play in the regulation of apoptosis in cancer cells?
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MicroRNAs (miRNAs) play a crucial role in regulating apoptosis in cancer cells. They can act as either apoptotic or anti-apoptotic factors by modulating the expression levels of tumor inhibitor or oncogene genes, thus impacting the apoptosis pathways in cancer. Specifically, miRNAs like miR-192, miR-194, miR-215, miR-22, and miR-101 have been identified to be involved in apoptosis regulation in cancer cells. These miRNAs can influence key factors in the apoptotic pathways, such as p53 and its downstream targets like p21 and Mdm2, ultimately affecting cell survival and proliferation. Understanding the mechanisms by which miRNAs regulate apoptosis in cancer cells provides valuable insights for developing novel therapeutic strategies targeting these miRNAs to modulate apoptosis and improve cancer treatment outcomes.
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| Papers (4) | Insight |
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| MicroRNAs regulate apoptosis in cancer cells, impacting cell survival. They act as post-transcriptional gene expression regulators, influencing pathways crucial for cancer development and progression. | |
| MicroRNAs like miR-192/194/215 regulate apoptosis in cancer cells by influencing p53 activity, inducing cell cycle arrest, and modulating p53 regulators like Mdm2 and Chk2. | |
2 Citations | MicroRNAs can act as apoptotic or anti-apoptotic factors in cancer cells by modulating tumor inhibitor or oncogene gene expression, influencing apoptosis regulation in prostate cancer. |
6 Citations | MicroRNAs regulate apoptosis in cancer cells by acting as oncogenes or tumor suppressors, influencing gene expression, and serving as potential biomarkers for diagnosis and prognosis. |
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