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What role do stromal cells play in regulating the bone marrow microenvironment?

Extracellular matrix

Myeloid leukemia

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Stromal cells in the bone marrow microenvironment are pivotal in regulating hematopoiesis and influencing disease development. These cells, including mesenchymal stromal cells (MSCs), communicate with hematopoietic stem cells through cytokines, growth factors, and extracellular vesicles, impacting normal and malignant hematopoiesis. Genetic and functional alterations in stromal cells can contribute to leukemogenesis, creating a niche supportive of myeloid neoplasms. Single-cell technologies aid in dissecting the interactions between stromal cells and malignant hematopoiesis, offering insights for potential therapeutic strategies. Additionally, the extracellular matrix (ECM) produced by stromal cells plays a crucial role in coordinating cellular phenotypes within the niche, influencing cell maintenance and phenotype. Overall, stromal cells are essential regulators of the bone marrow microenvironment, impacting hematopoiesis and disease progression.

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Open access•Book Chapter•DOI Stromal Cells and Extracellular Vesicles 08 Mar 2023	Stromal cells regulate the bone marrow microenvironment by communicating with neighboring cells through cytokines, growth factors, and extracellular vesicles, crucial for haematopoiesis and potentially impacting cancer development and metastasis.
Open access•Journal Article•DOI A Question of Frame: The Role of the Bone Marrow Stromal Niche in Myeloid Malignancies Felix T.S. Chan, Slobodan Dmitrović - Show less +1 more 23 May 2023-HemaSphere	Stromal cells, particularly mesenchymal stromal cells and osteoblastic derivatives, influence normal hematopoiesis and contribute to myeloid malignancies by creating a supportive niche for leukemic cells in the bone marrow.
Journal Article•DOI Identification of phenotypically, functionally, and anatomically distinct stromal niche populations in human bone marrow based on single-cell RNA sequencing Hongzhe Li, Sandro Bräunig, Parashar Dhapolar, Göran Karlsson, Stefan Lang, Stefan Scheding - Show less +5 more 06 Mar 2023-eLife 1 Citations	Stromal cells in the bone marrow regulate hematopoiesis through distinct mechanisms, including niche organization, cell differentiation hierarchy, and cell-cell communication, influencing the bone marrow microenvironment.
Journal Article•DOI A Question of Frame: The Role of the Bone Marrow Stromal Niche in Myeloid Malignancies Chiara Tomasoni, Alice Pievani, Benedetta Rambaldi, Andrea Biondi, Marta Serafini - Show less +4 more 23 May 2023-HemaSphere	Stromal cells, particularly mesenchymal stromal cells and osteoblastic derivatives, influence normal hematopoiesis and contribute to myeloid malignancies by supporting leukemogenesis and creating a niche for neoplastic cells.
Open access•Posted Content•DOI Extracellular matrices of bone marrow stroma regulate cell phenotype and contribute to distinct stromal niches in vivo Andrew Stone, Emma Rand, Gabriel Thornes, Alasdair G. Kay, Amanda L. Barnes, Ian S. Hitchcock, Paul G. Genever - Show less +6 more 20 Jan 2023-bioRxiv	Stromal cells in the bone marrow regulate cell phenotype through secreted extracellular matrix proteins, influencing niche maintenance and cell behavior, highlighting their crucial role in the bone marrow microenvironment.

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