What's a role of PML protein in senescent cell?
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The PML protein plays a crucial role in senescent cells. It is involved in the activation of the senescence-associated secretory phenotype (SASP), which is a pro-inflammatory phenotype associated with cellular senescence . PML is required for the activation of NF-kB and SASP, and it regulates cytoplasmic NF-kB signaling through the CCF-cGAS-STING-TBK1 pathway . PML also interacts with the autophagy cargo receptor p62 and antagonistically regulates SASP . Additionally, PML accumulates at the nucleolar periphery during DNA damage-induced senescence and is associated with inactivation of RNA polymerase I and nucleolar segregation . PML nucleolar associations (PNAs) contribute to the sequestration and repair of unstable ribosomal DNA repeats, which is important for maintaining genomic integrity and aging . Furthermore, PML is associated with PML nuclear bodies (PML-NBs) in senescent cells, and its SUMOylation is regulated during senescence . PML-NBs are involved in the activation of the DNA damage response pathway, which is frequently activated in senescence .
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| Papers (4) | Insight |
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01 Jan 2014 | The PML protein plays a role in senescent cells by modulating the p53 and Rb pathways, promoting p53 modifications, and associating with Rb to potentially silence genes. |
| The PML protein is involved in senescence initiation in stressed cells by promoting PML-NB biogenesis and PML-NB-dependent senescence initiation. | |
07 Sep 2019 6 Citations | The PML protein in senescent cells is involved in the formation of persistent PML multi-protein nucleolar structures (PML-NDS) that associate with DNA damage markers, indicating a role in persistent DNA damage response. |
| The PML protein is required for the activation of NF-kB and the senescence-associated secretory phenotype (SASP) in senescent cells. It also helps maintain the integrity of colocalized HIRA and p62 foci in the cell nucleus. |
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