Which are the best compounds to stimulate human L cells in the distal colon regulate hunger and satiety?
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The most promising compounds to stimulate human L cells in the distal colon for regulating hunger and satiety include glucagon-like peptide-1 (GLP-1), peptide YY (PYY), and short-chain fatty acids (SCFAs) like propionate and butyrate. GLP-1 and PYY are anorectic gut hormones secreted by L-cells in response to nutrient ingestion . These hormones play a crucial role in appetite regulation and satiety. SCFAs, particularly propionate and butyrate, stimulate the release of GLP-1 and PYY from enteroendocrine L-cells, contributing to appetite control and reduced food intake . Additionally, compounds like oleoylethanolamide (OEA) produced in the proximal intestine also play a role in satiety by activating sensory fibers and feeding-controlling circuits in the brain . Overall, these compounds show potential in targeting L-cells to modulate hunger and satiety effectively.
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| Papers (5) | Insight |
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Open access•Dissertation 28 Apr 2015 6 Citations | Butyrate and 4-CMTB are effective compounds to stimulate human L cells in the distal colon, regulating hunger and satiety by inducing GLP-1 release. |
| Nutrients stimulating GLP-1 and PYY secretion in the distal colon regulate hunger. Colonic delivery systems enhance sustained release for appetite management, potentially preventing obesity and metabolic diseases. | |
5 Citations | Oleoylethanolamide (OEA) synthesized from dietary oleic acid stimulates L cells in the distal colon, regulating hunger and satiety through PPAR-α activation and neural pathways involving oxytocin and histamine. |
01 Jan 2014 | Inulin propionate ester, by increasing GLP-1 and PYY release, effectively regulates hunger and satiety in humans, potentially through a centrally mediated action rather than affecting gastric emptying. |
01 Jan 2018 | Inulin propionate ester is effective in stimulating human L cells in the distal colon to regulate hunger and satiety by increasing GLP-1 secretion, as shown in the study. |
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