M
Miia Kovalainen
Researcher at University of Oulu
Publications - 23
Citations - 865
Miia Kovalainen is an academic researcher from University of Oulu. The author has contributed to research in topics: Drug carrier & Adipose tissue. The author has an hindex of 12, co-authored 22 publications receiving 748 citations. Previous affiliations of Miia Kovalainen include Oulu University Hospital & University of Eastern Finland.
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Journal ArticleDOI
Immobilization of protein-coated drug nanoparticles in nanofibrillar cellulose matrices--enhanced stability and release.
Hanna Valo,Miia Kovalainen,Päivi Laaksonen,Merja R. Häkkinen,Seppo Auriola,Leena Peltonen,Markus Linder,Kristiina Järvinen,Jouni Hirvonen,Timo Laaksonen +9 more
TL;DR: It was demonstrated that by enclosing the functionalized protein coated itraconazole nanoparticles to the external nanofibrillar cellulose matrix notably increased their storage stability and enhanced the in vivo performance of the drug.
Journal ArticleDOI
Distinct Effects of Calorie Restriction and Resveratrol on Diet-Induced Obesity and Fatty Liver Formation
Eveliina Tauriainen,Mira Luostarinen,Essi Martonen,Piet Finckenberg,Miia Kovalainen,Anne Huotari,Karl-Heinz Herzig,Anne Lecklin,Eero Mervaala +8 more
TL;DR: CR provided superior protection against diet-induced obesity and fatty liver formation as compared to resveratrol, and the effects were associated with increased physical activity and ameliorated adipose tissue inflammation.
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Mesoporous Silicon (PSi) for Sustained Peptide Delivery: Effect of PSi Microparticle Surface Chemistry on Peptide YY3-36 Release
Miia Kovalainen,Juha Mönkäre,Ermei Mäkilä,Jarno Salonen,Vesa-Pekka Lehto,Karl-Heinz Herzig,Kristiina Järvinen +6 more
TL;DR: Improved bioavailability of PYY3-36 via TOPSi and the importance of surface chemistry of PSi on peptide release are clearly demonstrated and PSi represents a promising sustained and tailorable release system for PYY 3-36.
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Effect of isotonic solutions and peptide adsorption on zeta potential of porous silicon nanoparticle drug delivery formulations.
Martti Kaasalainen,Ermei Mäkilä,Joakim Riikonen,Miia Kovalainen,Kristiina Järvinen,Karl-Heinz Herzig,Vesa-Pekka Lehto,Jarno Salonen +7 more
TL;DR: The results show the notable effect of isotonic solutions and peptide adsorption on zeta potential of PSi nanosuspensions.
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Nanocrystal-based per-oral itraconazole delivery: superior in vitro dissolution enhancement versus Sporanox® is not realized in in vivo drug absorption.
Annika Sarnes,Miia Kovalainen,Merja R. Häkkinen,Timo Laaksonen,Johanna Laru,Juha Kiesvaara,Jukka Ilkka,Olli Oksala,Seppo Rönkkö,Kristiina Järvinen,Jouni Hirvonen,Leena Peltonen +11 more
TL;DR: In this study, solid oral nanocrystal delivery systems of itraconazole were formulated to enhance the oral bioavailability of the very poorly soluble drug and out-performed the nanocrystalline formulations in vivo, but the efficient in vitro dissolution enhancement of thenanocrystal formulations compared to Sporanox® was not realized in in vivo drug absorption.