G
Gary Frost
Researcher at Imperial College London
Publications - 420
Citations - 27452
Gary Frost is an academic researcher from Imperial College London. The author has contributed to research in topics: Appetite & Type 2 diabetes. The author has an hindex of 74, co-authored 385 publications receiving 23418 citations. Previous affiliations of Gary Frost include King's College London & Hammersmith Hospital.
Papers
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Journal ArticleDOI
Ghrelin enhances appetite and increases food intake in humans.
Alison M. Wren,L. J. Seal,Mark Cohen,Audrey E. Brynes,Gary Frost,Kevin Murphy,Waljit S. Dhillo,M. A. Ghatei,S.R. Bloom +8 more
TL;DR: Ghrelin is the first circulating hormone demonstrated to stimulate food intake in man and is a potentially important new regulator of the complex systems controlling food intake and body weight.
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Inhibition of food intake in obese subjects by peptide YY3-36.
Rachel L. Batterham,Mark Cohen,Sandra M. Ellis,Carel W. le Roux,Dominic J. Withers,Gary Frost,Mohammad A. Ghatei,Stephen R. Bloom +7 more
TL;DR: It is found that obese subjects were not resistant to the anorectic effects of PYY, and endogenous PYY levels were low in obese subjects, suggesting that PYY deficiency may contribute to the pathogenesis of obesity.
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The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism
Gary Frost,Michelle L. Sleeth,Meliz Sahuri-Arisoylu,Blanca Lizarbe,Sebastián Cerdán,Leigh Brody,Jelena Anastasovska,Samar Ghourab,Mohammed K. Hankir,Shuai Zhang,David Carling,Jonathan R. Swann,Glenn R. Gibson,Alexander Viardot,Douglas J. Morrison,E. Louise Thomas,Jimmy D. Bell +16 more
TL;DR: It is demonstrated through 13C high-resolution magic-angle-spinning that 13C acetate from fermentation of 13C-labelled carbohydrate in the colon increases hypothalamic 13Cacetate above baseline levels, suggesting that acetate has a direct role in central appetite regulation.
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Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults
Edward S. Chambers,Alexander Viardot,Arianna Psichas,Douglas J. Morrison,Kevin G Murphy,Sagen Zac-Varghese,Kenneth MacDougall,Tom Preston,Catriona Tedford,Graham Finlayson,John E. Blundell,Jimmy D. Bell,E. Louise Thomas,Shahrul Mt-Isa,Deborah Ashby,Glen R. Gibson,Sofia Kolida,Walijit S. Dhillo,Stephen R. Bloom,Wayne Morley,Stuart Clegg,Gary Frost +21 more
TL;DR: It is demonstrated for the first time that increasing colonic propionate prevents weight gain in overweight adult humans.
Journal ArticleDOI
Oxyntomodulin Suppresses Appetite and Reduces Food Intake in Humans
Mark Cohen,Sandra M. Ellis,Carel W. le Roux,Rachel L. Batterham,Adrian Park,Michael Patterson,Gary Frost,Mohammad A. Ghatei,Stephen R. Bloom +8 more
TL;DR: Elevated levels of endogenous OXM associated with disorders of the gastrointestinal tract may contribute to anorexia, and central injection of OXM reduces food intake and weight gain in rodents.